Department of Epidemiology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology, Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran.
Epidemiol Health. 2019;41:e2019030. doi: 10.4178/epih.e2019030. Epub 2019 Jul 4.
Depression, which is the most common comorbidity in breast cancer (BC) patients, has adverse effects on patients' quality of life, disease progress, and survival.
The protocol of this study was registered in PROSPERO (registration No. CRD42019121494). We electronically searched published studies through January 2019 with the aim of finding articles that investigated the prevalence of depression among BC survivors. Web of Science, Scopus, PubMed/MEDLINE, Science Direct, and Google Scholar were searched to obtain relevant published studies. This review included 14 cross-sectional and 4 cohort studies published from 2000 to 2018. We used a random-effects model to conduct the meta-analysis and generated a summary estimate for the pooled prevalence with 95% confidence intervals (CIs). A subgroup analysis was also conducted based on the depression assessment tool used and the study design.
The total sample size of the studies contained 2,799 women with BC, including 1,228 women who were diagnosed with depression. The pooled prevalence of depression among Iranian women with BC was 46.83% (95% CI, 33.77 to 59.88) with significant heterogeneity (I2 =98.5%; p<0.001). The prevalence of depression ranged from 14.00% (95% CI, 4.91 to 23.09) to 95.90% (95% CI, 91.97 to 99.83). The results of the subgroup analyses suggested that the depression assessment tool, year of publication, and study design were sources of heterogeneity.
Our findings indicate a high prevalence of depression among BC patients, underscoring the urgent need for clinicians and health authorities to provide well-defined social and psychological supportive care programs for these patients.
抑郁症是乳腺癌（BC）患者最常见的合并症，对患者的生活质量、疾病进展和生存都有不良影响。
本研究的方案已在 PROSPERO（注册号 CRD42019121494）注册。我们通过电子检索，搜索了截至 2019 年 1 月发表的研究，旨在寻找调查 BC 幸存者中抑郁症患病率的文章。我们检索了 Web of Science、Scopus、PubMed/MEDLINE、Science Direct 和 Google Scholar，以获取相关的已发表研究。本综述包括 2000 年至 2018 年发表的 14 项横断面研究和 4 项队列研究。我们使用随机效应模型进行荟萃分析，并生成汇总估计值，以获得 95%置信区间（CI）的合并患病率。还根据使用的抑郁评估工具和研究设计进行了亚组分析。
研究的总样本量包括 2799 名 BC 女性，其中 1228 名女性被诊断患有抑郁症。伊朗 BC 女性的抑郁症总患病率为 46.83%（95%CI，33.77 至 59.88），异质性显著（I2=98.5%；p<0.001）。抑郁症的患病率范围从 14.00%（95%CI，4.91 至 23.09）到 95.90%（95%CI，91.97 至 99.83）。亚组分析的结果表明，抑郁评估工具、发表年份和研究设计是异质性的来源。
我们的研究结果表明，BC 患者的抑郁症患病率较高，这突显了临床医生和卫生当局迫切需要为这些患者提供明确的社会和心理支持护理计划。
