Rezaei-Tavirani Mostafa, Safaei Akram, Zali Mohammad Reza
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroentrology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Cancer Prev. 2013 Fall;6(4):179-85.
Colon cancer is the cancer of the large intestine (colon), which is located in the lower part of digestive system. Colon cancer is the third most common cancer in men and the second in women worldwide.Genetic background is thought to play a role in modulating individual risks of this cancer.Many studies support an association between insulin pathway gene polymorphisms and regulation of tumor cell biology in colorectal cancer. This review examines the role of polymorphisms of insulin and obesity pathway genes (IGFs, INS, INSR, ADIPOQ, ADIPOQR, LEP and LEPR) in development of colorectal cancer.
结肠癌是位于消化系统下部的大肠（结肠）癌症。在全球范围内，结肠癌是男性中第三大常见癌症，女性中第二大常见癌症。遗传背景被认为在调节个体患这种癌症的风险中起作用。许多研究支持胰岛素通路基因多态性与结直肠癌肿瘤细胞生物学调节之间的关联。本综述探讨胰岛素和肥胖通路基因（胰岛素样生长因子、胰岛素、胰岛素受体、脂联素、脂联素受体、瘦素和瘦素受体）的多态性在结直肠癌发生中的作用。
