State Key Laboratory of Bioelectronics, Southeast University, Nanjing, 210096, China.
Adv Mater. 2014 Nov 19;26(43):7333-8. doi: 10.1002/adma.201403530. Epub 2014 Sep 23.
Aptamer-functionalized barcode particles are employed to capture and detect various types of circulating tumor cells (CTCs). The particles are spherical colloidal crystal clusters, and the reflection properties that arise from their structures are how their codes are evaluated. Aptamer functionalization (with TD05, Sgc8, and Sgd5) make the particles interact with specific CTC types; dendrimers are used to amplify the effect of the aptamers, allowing for increased sensitivity, reliability, and specificity in CTC capture, detection, and subsequent release.
适配体功能化的条码颗粒被用于捕获和检测各种类型的循环肿瘤细胞（CTCs）。这些颗粒是球形胶体晶体簇，其结构产生的反射特性是评估其编码的方式。适配体功能化（使用 TD05、Sgc8 和 Sgd5）使颗粒与特定的 CTC 类型相互作用；树枝状聚合物被用来放大适配体的作用，从而提高 CTC 捕获、检测以及随后释放的灵敏度、可靠性和特异性。
