†Laboratory of Advanced Materials, Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, P. R. China.
‡King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia.
J Am Chem Soc. 2015 May 13;137(18):5903-6. doi: 10.1021/jacs.5b03207. Epub 2015 Apr 30.
Asymmetric single-hole mesoporous silica nanocages, which are eccentric hollow structured spheres and consist of mesoporous shell with an open hole on their surface, with uniform particle size (100-240 nm), have successfully been synthesized via a novel anisotropic encapsulation of the mesoporous silica. In this unique nanocarrier, the eccentric hollow cavity and big hole (∼25 nm) can serve as a storage space and passage for large guest molecules. Meanwhile, the uniform mesopores (2-10 nm) with a high surface area (∼500 m(2)/g) in the silica shells of the nanocages can provide storage space for small guest molecules. The obtained single-hole mesoporous nanocages can be endowed upconversion luminescence. The obtained upconversion nanoparticles functionalized eccentric single-hole nanorattles were used to codeliver bovine serum albumin and doxorubicin dual-sized guests. The release of the dual-sized guests can be well controlled independently by heat and near-infrared (NIR) light with the assistance of NIR to ultraviolet/visible (UV/vis) optical properties of upconversion nanoparticles and heat-sensitive phase change materials.
不对称单孔介孔硅纳米笼是一种偏心中空结构的球形纳米材料，由介孔壳层组成，表面有一个开口孔，粒径均匀（100-240nm），通过介孔硅的新型各向异性封装成功合成。在这个独特的纳米载体中，偏心的中空腔和大孔（25nm）可以作为大客体分子的储存空间和通道。同时，纳米笼的介孔（2-10nm）具有高的比表面积（500m²/g），可以为小分子客体提供储存空间。所得的单孔介孔纳米笼可以赋予上转换发光性能。所得的功能化偏心单孔纳米摇瓶的上转换纳米粒子可用于共递送牛血清白蛋白和阿霉素两种大小的客体分子。在近红外（NIR）光的辅助下，通过上转换纳米粒子的 NIR 到紫外/可见（UV/vis）光学性质和热敏相变材料，可以很好地分别控制两种大小客体分子的释放。
