Kroese Lona J, Scheffer Peter G
Institute for Cardiovascular Research, VU University Medical Center, Amsterdam, The Netherlands.
Curr Atheroscler Rep. 2014 Nov;16(11):452. doi: 10.1007/s11883-014-0452-y.
Oxidative stress due to an excess of reactive oxygen species (ROS) may play a role in the development and progression of cardiovascular disease (CVD). 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a marker of oxidative DNA damage caused by ROS. This review aimed to assess the association between 8-OHdG and CVD by reviewing the literature. Studies in human subjects using either plasma or urine to determine 8-OHdG concentrations were surveyed. Eighteen relevant studies were found, of which 13 were case-control studies and five had a prospective design. Without exception, the case-control studies showed significant positive associations between 8-OHdG and CVD. In agreement, two prospective studies showed a significant association of 8-OHdG and heart failure. Furthermore, two prospective studies found a significant association between 8-OHdG and stroke, and finally, one prospective study showed a borderline significant (p = 0.08) association between coronary artery disease (CAD) patients developing a cardiac event and 8-OHdG concentrations. In conclusion, high levels of 8-OHdG in blood and urine are associated with atherosclerosis and heart failure, but further large prospective studies are needed to investigate 8-OHdG as a predictor for cardiovascular diseases.
由于活性氧（ROS）过量导致的氧化应激可能在心血管疾病（CVD）的发生和发展中起作用。8-羟基-2'-脱氧鸟苷（8-OHdG）是由ROS引起的氧化DNA损伤的标志物。本综述旨在通过回顾文献来评估8-OHdG与CVD之间的关联。对使用血浆或尿液来测定8-OHdG浓度的人体研究进行了调查。共发现18项相关研究，其中13项为病例对照研究，5项为前瞻性设计。无一例外，病例对照研究显示8-OHdG与CVD之间存在显著正相关。同样，两项前瞻性研究显示8-OHdG与心力衰竭之间存在显著关联。此外，两项前瞻性研究发现8-OHdG与中风之间存在显著关联，最后，一项前瞻性研究显示冠状动脉疾病（CAD）患者发生心脏事件与8-OHdG浓度之间存在临界显著关联（p = 0.08）。总之，血液和尿液中高水平的8-OHdG与动脉粥样硬化和心力衰竭相关，但需要进一步开展大型前瞻性研究来探究8-OHdG作为心血管疾病预测指标的情况。
