系统性硬化症、精氨酸和不对称二甲基精氨酸之间的关系。
The association between systemic sclerosis, arginine and asymmetric dimethylarginine.
机构信息
Medical Genetics Center, Anhui Medical College, Hefei, China.
出版信息
Inflammation. 2015 Feb;38(1):218-23. doi: 10.1007/s10753-014-0025-9.
Systemic sclerosis (SSc) is a kind of autoimmune disease characterized by inflammatory and endothelial dysfunction. Asymmetric dimethylarginine (ADMA), as an endogenous nitric oxide synthase inhibitor, can cause or contribute to the inflammatory syndrome and endothelial dysfunction. Recently, increased ADMA levels have been demonstrated in SSc, revealing that ADMA might play an important role for the associated manifestations of SSc. Besides, ADMA may play a significant role in the level of NO, which is produced by arginine. In the review, we discuss the role of arginine and ADMA in patients with SSc.
系统性硬化症（SSc）是一种自身免疫性疾病，其特征为炎症和内皮功能障碍。不对称二甲基精氨酸（ADMA）作为一种内源性一氧化氮合酶抑制剂，可引起或促成炎症综合征和内皮功能障碍。最近，在 SSc 患者中发现 ADMA 水平升高，这表明 ADMA 可能对 SSc 的相关表现起重要作用。此外，ADMA 可能在由精氨酸产生的一氧化氮（NO）水平中发挥重要作用。在这篇综述中，我们讨论了精氨酸和 ADMA 在 SSc 患者中的作用。
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