State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zu Chong Zhi Road, Shanghai 201203, People's Republic of China.
J Nat Prod. 2014 Oct 24;77(10):2224-33. doi: 10.1021/np5004752. Epub 2014 Sep 25.
Eighteen new diterpenoids, named eurifoloids A-R (1-18), including ingenane (1 and 2), abietane (3-7), isopimarane (8-12), and ent-atisane (13-18) types, along with four known analogues were isolated from Euphorbia neriifolia. Eurifoloid M (13) represents a rare class of ent-atisane-type norditerpenoid. Eurifoloids E (5) and F (6) exhibited significant anti-HIV activities, with EC50 values of 3.58 ± 0.31 (SI = 8.6) and 7.40 ± 0.94 μM (SI = 10.3), respectively.
从大戟属植物白泽中分离得到 18 种新二萜类化合物，分别命名为 eurifoloids A-R（1-18），包括 ingenane（1 和 2）、abietane（3-7）、isopimarane（8-12）和 ent-atisane（13-18）类型，以及 4 种已知类似物。Eurifoloid M（13）代表了一类罕见的 ent-atisane 型 Norditerpenoid。Eurifoloids E（5）和 F（6）表现出显著的抗 HIV 活性，EC50 值分别为 3.58 ± 0.31（SI = 8.6）和 7.40 ± 0.94 μM（SI = 10.3）。
