来自麻风树茎皮的二萜类化合物及其体外抗HIV活性。
Diterpenes from the stem bark of Euphorbia neriifolia and their in vitro anti-HIV activity.
作者信息
Yan Shi-Li, Li Yan-Hong, Chen Xuan-Qin, Liu Dan, Chen Chin-Ho, Li Rong-Tao
机构信息
Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, PR China.
Surgical Science, Department of Surgery, Duke University Medical Center, Durham, NC, USA.
出版信息
Phytochemistry. 2018 Jan;145:40-47. doi: 10.1016/j.phytochem.2017.10.006. Epub 2017 Nov 5.
Six previously undescribed diterpenoids, named euphorantins S-T and euphorneroids A-D, including ingol and ent-atisane types, along with eleven known diterpenoids, were isolated from Euphorbia neriifolia. Their structures were elucidated on the basis of extensive NMR analysis and high resolution mass spectrometry. Euphorneroid D and ent-3-oxoatisan-16α,17-acetonide exhibited moderate anti-HIV-1 activities, with EC values of 34 μM (SI = 2.3) and 24 μM (SI = 1.9), respectively.
从大戟科植物麻风树中分离出6个新的二萜类化合物，分别命名为大戟素S - T和大戟新甾体A - D，包括英戈尔型和对映-乌苏烷型，以及11个已知的二萜类化合物。通过广泛的核磁共振分析和高分辨率质谱对其结构进行了阐明。大戟新甾体D和对映-3-氧代乌苏烷-16α,17-丙酮化物表现出中等的抗HIV-1活性，其半数有效浓度（EC）值分别为34 μM（选择性指数SI = 2.3）和24 μM（SI = 1.9）。
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