Key Laboratory of Biology and Genetic Resources of Tropical Crops, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, PR China.
Fitoterapia. 2014 Jun;95:34-41. doi: 10.1016/j.fitote.2014.02.018. Epub 2014 Mar 5.
Three tigliane-type diterpenoids named excoecafolins A-C and two daphnane-type diterpenoids named excoecafolins D and E, together with 13 known compounds, were isolated from the EtOAc extract of Excoecaria acerifolia Didr. Their structures were elucidated through the analysis of the spectroscopic data. The anti-HIV-1 activity evaluation of five of these compounds showed that four possessed moderate anti-HIV-1 activities with EC50 0.258, 0.036, 0.046, and 0.978 μM, SI >1,836.9, 431.1, 298.7, and >503.7, respectively. Additionally, the chemotaxonomic issue of the affinity correlation between Thymelaeceae and Euphorbiaceae is discussed based on the isolates.
从飞扬草（Excoecaria acerifolia Didr.）的乙酸乙酯提取物中分离得到了三种名为 excoecafolins A-C 的三萜型二萜类化合物和两种名为 excoecafolins D 和 E 的二萜类化合物，以及 13 种已知化合物。通过分析光谱数据阐明了它们的结构。对这 5 种化合物的抗 HIV-1 活性评价表明，其中 4 种具有中等抗 HIV-1 活性，EC50 分别为 0.258、0.036、0.046 和 0.978 μM，SI >1,836.9、431.1、298.7 和 >503.7。此外，还基于这些分离物讨论了 Thymelaeceae 和 Euphorbiaceae 之间亲缘关系的化学分类学问题。
