慢性丙型肝炎病毒感染的肝外免疫相关表现
Extrahepatic immune related manifestations in chronic hepatitis C virus infection.
作者信息
Tampaki Maria, Koskinas John
机构信息
Maria Tampaki, John Koskinas, Academic Department of Medicine, Medical School of Athens, Hippokration General Hospital, Athens 17123, Greece.
出版信息
World J Gastroenterol. 2014 Sep 21;20(35):12372-80. doi: 10.3748/wjg.v20.i35.12372.
The association of chronic hepatitis C with immune related syndromes has been frequently reported. There is a great range of clinical manifestations affecting various systems and organs such as the skin, the kidneys, the central and peripheral nervous system, the musculoskeletal system and the endocrine glands. Despite the high prevalence of immune related syndromes in patients with chronic hepatitis C, the exact pathogenesis is not always clear. They have been often associated with mixed cryoglobulinemia, a common finding in chronic hepatitis C, cross reaction with viral antigens, or the direct effect of virus on the affected tissues. The aim of this review is to analyze the reported hepatitis C virus immune mediated syndromes, their prevalence and clinical manifestations and to discuss the most supported theories regarding their pathogenesis.
慢性丙型肝炎与免疫相关综合征的关联已屡有报道。其临床表现多样，累及皮肤、肾脏、中枢和外周神经系统、肌肉骨骼系统及内分泌腺等多个系统和器官。尽管慢性丙型肝炎患者中免疫相关综合征的患病率很高，但其确切发病机制并不总是明确。它们常与混合性冷球蛋白血症（慢性丙型肝炎的常见表现）、与病毒抗原的交叉反应或病毒对受影响组织的直接作用有关。本综述旨在分析已报道的丙型肝炎病毒免疫介导综合征、其患病率和临床表现，并讨论关于其发病机制的最受支持的理论。
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