免疫反应与结直肠癌：朋友还是敌人？
Immune reaction and colorectal cancer: friends or foes?
作者信息
Formica Vincenzo, Cereda Vittore, Nardecchia Antonella, Tesauro Manfredi, Roselli Mario
机构信息
Vincenzo Formica, Vittore Cereda, Antonella Nardecchia, Mario Roselli, Medical Oncology Unit, 'Tor Vergata' University Hospital, 00133 Rome, Italy.
出版信息
World J Gastroenterol. 2014 Sep 21;20(35):12407-19. doi: 10.3748/wjg.v20.i35.12407.
Abstract
The potential clinical impact of enhancing antitumor immunity is increasingly recognized in oncology therapeutics for solid tumors. Colorectal cancer is one of the most studied neoplasms for the tumor-host immunity relationship. Although immune cell populations involved in such a relationship and their prognostic role in colorectal cancer development have clearly been identified, still no approved therapies based on host immunity intensification have so far been introduced in clinical practice. Moreover, a recognized risk in enhancing immune reaction for colitis-associated colorectal cancer development has limited the emphasis of this approach. The aim of the present review is to discuss immune components involved in the host immune reaction against colorectal cancer and analyze the fine balance between pro-tumoral and anti-tumoral effect of immunity in this model of disease.
摘要
在实体瘤的肿瘤学治疗中，增强抗肿瘤免疫力的潜在临床影响日益受到认可。结直肠癌是肿瘤-宿主免疫关系研究最多的肿瘤之一。尽管参与这种关系的免疫细胞群体及其在结直肠癌发生中的预后作用已被明确识别，但迄今为止，临床实践中尚未引入基于增强宿主免疫力的获批疗法。此外，对于与结肠炎相关的结直肠癌发生，增强免疫反应存在公认的风险，这限制了该方法的应用。本综述的目的是讨论参与宿主针对结直肠癌免疫反应的免疫成分，并分析在这种疾病模型中免疫的促肿瘤和抗肿瘤作用之间的微妙平衡。
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