• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells.DEPTOR是一种调节胚胎干细胞多能性的干性因子。
J Biol Chem. 2014 Nov 14;289(46):31818-31826. doi: 10.1074/jbc.M114.565838. Epub 2014 Sep 25.
2
p65 down-regulates DEPTOR expression in response to LPS stimulation in hepatocytes.在肝细胞中，p65响应脂多糖（LPS）刺激而下调DEPTOR的表达。
Gene. 2016 Sep 1;589(1):12-19. doi: 10.1016/j.gene.2016.05.014. Epub 2016 May 12.
3
DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis.DEPTOR 通过抑制 MEG3 介导的 BMP4 信号激活来调节成骨分化，并且与骨质疏松症有关。
Stem Cell Res Ther. 2018 Jul 4;9(1):185. doi: 10.1186/s13287-018-0935-9.
4
Elucidating the role of DEPTOR in Alzheimer's disease.阐明DEPTOR在阿尔茨海默病中的作用。
Int J Mol Med. 2014 Nov;34(5):1195-200. doi: 10.3892/ijmm.2014.1895. Epub 2014 Aug 12.
5
Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth.DepTOr 是 Wnt/β-catenin/c-Myc 的一个新靶点，并促进结直肠癌细胞生长。
Cancer Res. 2018 Jun 15;78(12):3163-3175. doi: 10.1158/0008-5472.CAN-17-3107. Epub 2018 Apr 17.
6
Ethyl-p-methoxycinnamate enhances oct4 expression and reinforces pluripotency through the NF-κB signaling pathway.对甲氧基肉桂酸乙酯通过 NF-κB 信号通路增强 oct4 表达并加强多能性。
Biochem Pharmacol. 2020 Jul;177:113984. doi: 10.1016/j.bcp.2020.113984. Epub 2020 Apr 18.
7
Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway.雷帕霉素通过阻断 mTOR 通路和刺激 BMP/Smad 通路促进人胚胎干细胞的成骨分化。
Stem Cells Dev. 2010 Apr;19(4):557-68. doi: 10.1089/scd.2009.0147.
8
Trib2 regulates the pluripotency of embryonic stem cells and enhances reprogramming efficiency.Trib2 调节胚胎干细胞的多能性并提高重编程效率。
Exp Mol Med. 2017 Nov 24;49(11):e401. doi: 10.1038/emm.2017.191.
9
Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy.DepTor 敲低可增强肌细胞中的 mTOR 活性和蛋白质合成，并改善废用性肌肉萎缩。
Mol Med. 2011 Sep-Oct;17(9-10):925-36. doi: 10.2119/molmed.2011.00070. Epub 2011 May 19.
10
TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression.转化生长因子β诱导的去磷酸化蛋白抑制作用招募哺乳动物雷帕霉素靶蛋白复合物1（mTORC1）而非哺乳动物雷帕霉素靶蛋白复合物2（mTORC2）来增强I型胶原蛋白（α2）基因表达。
PLoS One. 2014 Oct 15;9(10):e109608. doi: 10.1371/journal.pone.0109608. eCollection 2014.

引用本文的文献

1
Methylseq, single-nuclei RNAseq, and discovery proteomics identify pathways associated with nephron-deficit CKD in the HSRA rat model.甲基化测序、单细胞核RNA测序和发现蛋白质组学确定了HSRA大鼠模型中与肾单位缺陷型慢性肾脏病相关的通路。
Am J Physiol Renal Physiol. 2025 Apr 1;328(4):F470-F488. doi: 10.1152/ajprenal.00258.2024. Epub 2025 Feb 21.
2
Identification of functional circRNAs regulating ovarian follicle development in goats.鉴定调控山羊卵泡发育的功能性 circRNAs。
BMC Genomics. 2024 Sep 28;25(1):893. doi: 10.1186/s12864-024-10834-w.
3
Mitochondrial metabolism in neural stem cells and implications for neurodevelopmental and neurodegenerative diseases.神经干细胞中的线粒体代谢及其对神经发育和神经退行性疾病的影响。
J Transl Med. 2024 Mar 4;22(1):238. doi: 10.1186/s12967-024-05041-w.
4
Selective Inhibition of mTORC1 Signaling Supports the Development and Maintenance of Pluripotency.选择性抑制 mTORC1 信号支持多能性的发育和维持。
Stem Cells. 2024 Jan 13;42(1):13-28. doi: 10.1093/stmcls/sxad079.
5
Membrane potential drives the exit from pluripotency and cell fate commitment via calcium and mTOR.膜电位通过钙和 mTOR 驱动多能性的退出和细胞命运的决定。
Nat Commun. 2022 Nov 5;13(1):6681. doi: 10.1038/s41467-022-34363-w.
6
The Interaction of and in Neurogenesis and Its Implication in Neurodegenerative Diseases.和在神经发生中的相互作用及其在神经退行性疾病中的意义。
Cells. 2022 Jun 28;11(13):2048. doi: 10.3390/cells11132048.
7
In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes.深入的蛋白质组分析强调 HepaRG 细胞作为原发性人肝细胞的多功能细胞系统替代物。
Cells. 2019 Feb 21;8(2):192. doi: 10.3390/cells8020192.
8
Differential regulation of mTORC1 and mTORC2 is critical for 8-Br-cAMP-induced decidualization.mTORC1 和 mTORC2 的差异调节对于 8-Br-cAMP 诱导的蜕膜化至关重要。
Exp Mol Med. 2018 Oct 30;50(10):1-11. doi: 10.1038/s12276-018-0165-3.
9
DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis.DEPTOR 通过抑制 MEG3 介导的 BMP4 信号激活来调节成骨分化，并且与骨质疏松症有关。
Stem Cell Res Ther. 2018 Jul 4;9(1):185. doi: 10.1186/s13287-018-0935-9.
10
DEPTOR at the Nexus of Cancer, Metabolism, and Immunity.DEPTOR 在癌症、代谢和免疫的交汇点。
Physiol Rev. 2018 Jul 1;98(3):1765-1803. doi: 10.1152/physrev.00064.2017.

本文引用的文献

1
Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency.通过 Sox2 介导的 mTOR 抑制来短暂激活自噬，是重编程为多能性的重要早期步骤。
Cell Stem Cell. 2013 Nov 7;13(5):617-25. doi: 10.1016/j.stem.2013.10.005.
2
Autophagy regulates homeostasis of pluripotency-associated proteins in hESCs.自噬调节 hESC 中多能性相关蛋白的内稳态。
Stem Cells. 2014 Feb;32(2):424-35. doi: 10.1002/stem.1589.
3
LASAGNA-Search: an integrated web tool for transcription factor binding site search and visualization.LASAGNA-Search：一个用于转录因子结合位点搜索和可视化的集成网络工具。
Biotechniques. 2013 Mar;54(3):141-53. doi: 10.2144/000113999.
4
Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response.泛素依赖性调控磷酸化 AKT 动力学由泛素 E3 连接酶，NEDD4-1，在胰岛素样生长因子-1 反应中。
J Biol Chem. 2013 Jan 18;288(3):1674-84. doi: 10.1074/jbc.M112.416339. Epub 2012 Nov 29.
5
Notch-mediated suppression of TSC2 expression regulates cell differentiation in the Drosophila intestinal stem cell lineage.Notch 信号通路抑制 TSC2 表达调控果蝇肠道干细胞谱系中的细胞分化。
PLoS Genet. 2012;8(11):e1003045. doi: 10.1371/journal.pgen.1003045. Epub 2012 Nov 8.
6
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis.mTOR 复合物 1 在造血和 Pten 缺失诱导的白血病发生中发挥关键作用。
Cell Stem Cell. 2012 Sep 7;11(3):429-39. doi: 10.1016/j.stem.2012.06.009.
7
DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.DEPTOR 细胞自主促进脂肪生成，其表达与肥胖有关。
Cell Metab. 2012 Aug 8;16(2):202-12. doi: 10.1016/j.cmet.2012.07.008.
8
Production and transplantation of retinal cells from human and mouse embryonic stem cells.来自人类和小鼠胚胎干细胞的视网膜细胞的产生与移植。
Methods Mol Biol. 2012;884:229-46. doi: 10.1007/978-1-61779-848-1_16.
9
Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling.BMP、视黄酸和 Notch 信号通路高效诱导胚胎干细胞向中胚层前体细胞分化。
PLoS One. 2012;7(4):e36405. doi: 10.1371/journal.pone.0036405. Epub 2012 Apr 30.
10
Ubiquitin-specific peptidase 9, X-linked (USP9X) modulates activity of mammalian target of rapamycin (mTOR).泛素特异性肽酶 9，X 连锁（USP9X）调节哺乳动物雷帕霉素靶蛋白（mTOR）的活性。
J Biol Chem. 2012 Jun 15;287(25):21164-75. doi: 10.1074/jbc.M111.328021. Epub 2012 Apr 27.

DEPTOR是一种调节胚胎干细胞多能性的干性因子。

DEPTOR is a stemness factor that regulates pluripotency of embryonic stem cells.

作者信息

Agrawal Pooja, Reynolds Joseph, Chew Shereen, Lamba Deepak A, Hughes Robert E

机构信息

Buck Institute for Research on Aging, Novato, California 94945 and.

Buck Institute for Research on Aging, Novato, California 94945 and; Department of Ophthalmology, University of Washington, Seattle, Washington 98104.

出版信息

J Biol Chem. 2014 Nov 14;289(46):31818-31826. doi: 10.1074/jbc.M114.565838. Epub 2014 Sep 25.

DOI:10.1074/jbc.M114.565838
PMID:25258312
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4231659/
Abstract

The mammalian target of rapamycin (mTOR) pathway regulates stem cell regeneration and differentiation in response to growth factors, nutrients, cellular energetics, and various extrinsic stressors. Inhibition of mTOR activity has been shown to enhance the regenerative potential of pluripotent stem cells. DEPTOR is the only known endogenous inhibitor of all known cellular mTOR functions. We show that DEPTOR plays a key role in maintaining stem cell pluripotency by limiting mTOR activity in undifferentiated embryonic stem cells (ESCs). DEPTOR levels dramatically decrease with differentiation of mouse ESCs, and knockdown of DEPTOR is sufficient to promote ESC differentiation. A strong decrease in DEPTOR expression is also observed during human ESCs differentiation. Furthermore, reduction in DEPTOR level during differentiation is accompanied by a corresponding increase in mTOR complex 1 activity in mouse ESCs. Our data provide evidence that DEPTOR is a novel stemness factor that promotes pluripotency and self-renewal in ESCs by inhibiting mTOR signaling.

摘要

雷帕霉素哺乳动物靶点（mTOR）通路可响应生长因子、营养物质、细胞能量代谢及各种外在应激源，调节干细胞的再生与分化。已有研究表明，抑制mTOR活性可增强多能干细胞的再生潜能。DEPTOR是所有已知细胞mTOR功能的唯一内源性抑制剂。我们发现，DEPTOR通过限制未分化胚胎干细胞（ESC）中的mTOR活性，在维持干细胞多能性方面发挥关键作用。随着小鼠ESC的分化，DEPTOR水平显著降低，敲低DEPTOR足以促进ESC分化。在人类ESC分化过程中也观察到DEPTOR表达大幅下降。此外，在小鼠ESC分化过程中，DEPTOR水平的降低伴随着mTOR复合物1活性的相应增加。我们的数据表明，DEPTOR是一种新型干性因子，通过抑制mTOR信号促进ESC的多能性和自我更新。