Dobrić I, Basta-Juzbasić A, Skerlev M
Acta Med Iugosl. 1989;43(2):127-36.
The results of the oxytetracycline therapy given orally to 26 patients with severe papulopustular rosacea are presented. The biopsies were taken at the most typical sites. In 19 out of 26 patients the pathological changes characteristic of papulopustular rosacea were found. In 7 out of 26 patients epitheloid granulomas without central caseation were histologically observed. In these 7 patients tuberculosis was excluded (the absence of other tuberculous stigmata, normal laboratory data). Tetracycline (oxytetracycline) was given orally to 26 patients. One month later, a remarkable clinical improvement could be seen, i.e. the papules and pustules disappeared in all 26 patients and the recurrence of the disease could not be noticed in any patient during a 2.5-year-observation period. As no signs of tuberculosis could be detected in these patients, the authors believe that rosaceiform changes with epitheloid granulomas should be systematized in rosacea as "rosacea-like eruptions". A good therapeutic response of "rosacea-like eruptions" to tetracyclines could possibly confirm the authors' hypothesis.
本文介绍了对26例重度丘疹脓疱型酒渣鼻患者口服土霉素治疗的结果。活检取自最典型的部位。26例患者中有19例发现了丘疹脓疱型酒渣鼻的特征性病理变化。26例患者中有7例在组织学上观察到无中央干酪样坏死的上皮样肉芽肿。在这7例患者中排除了结核病（无其他结核体征，实验室数据正常）。对26例患者口服四环素（土霉素）。1个月后，可见明显的临床改善，即所有26例患者的丘疹和脓疱均消失，在2.5年的观察期内未发现任何患者疾病复发。由于在这些患者中未检测到结核病迹象，作者认为伴有上皮样肉芽肿的酒渣鼻样改变应在酒渣鼻分类中作为“酒渣鼻样皮疹”进行系统化。“酒渣鼻样皮疹”对四环素的良好治疗反应可能证实了作者的假设。
