多发性硬化会影响骨骼肌特征。
Multiple sclerosis affects skeletal muscle characteristics.
作者信息
Wens Inez, Dalgas Ulrik, Vandenabeele Frank, Krekels Maartje, Grevendonk Lotte, Eijnde Bert O
机构信息
REVAL - Rehabilitation Research Center, BIOMED - Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.
Section of Sport Science, Dep. Public Health, Aarhus University, Aarhus C, Denmark.
出版信息
PLoS One. 2014 Sep 29;9(9):e108158. doi: 10.1371/journal.pone.0108158. eCollection 2014.
BACKGROUND
The impact of multiple sclerosis (MS) on skeletal muscle characteristics, such as muscle fiber cross sectional area (CSA), fiber type proportion, muscle strength and whole muscle mass, remains conflicting.
METHODS
In this cross sectional study, body composition and muscle strength of the quadriceps were assessed in 34 MS (EDSS: 2.5±0.19) patients and 18 matched healthy controls (HC). Hereafter a muscle biopsy (m.vastus lateralis) was taken.
RESULTS
Compared to HC, mean muscle fiber CSA of all fibers, as well as CSA of type I, II and IIa fibers were smaller and muscle strength of the quadriceps was lower in MS patients. Whole body composition was comparable between groups. However, compared to HC, the biopsied leg tended to have a higher fat percentage (p = 0.1) and a lower lean mass (p = 0.06) in MS patients.
CONCLUSION
MS seems to negatively influence skeletal muscle fiber CSA, muscle strength and muscle mass of the lower limbs of mildly affected MS patients. This emphasises the need for rehabilitation programs focusing on muscle preservation of the lower limb.
TRIAL REGISTRATION
ClinicalTrials.gov NCT01845896.
背景
多发性硬化症（MS）对骨骼肌特征的影响，如肌纤维横截面积（CSA）、纤维类型比例、肌肉力量和全肌肉质量，仍存在争议。
方法
在这项横断面研究中，对34例MS患者（扩展残疾状态量表：2.5±0.19）和18例匹配的健康对照者（HC）的身体成分和股四头肌力量进行了评估。此后进行了肌肉活检（外侧股四头肌）。
结果
与HC相比，MS患者所有纤维的平均肌纤维CSA以及I型、II型和IIa型纤维的CSA均较小，股四头肌力量较低。两组间全身成分相当。然而，与HC相比，MS患者活检侧下肢的脂肪百分比倾向于更高（p = 0.1），瘦体重更低（p = 0.06）。
结论
MS似乎对轻度受影响的MS患者下肢的骨骼肌纤维CSA、肌肉力量和肌肉质量有负面影响。这强调了需要开展侧重于下肢肌肉保护的康复项目。
试验注册
ClinicalTrials.gov NCT01845896。
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