基于Cirrus光谱域光学相干断层扫描技术的眼前节角度测量指标的可重复性
Reproducibility of anterior segment angle metrics measurements derived from Cirrus spectral domain optical coherence tomography.
作者信息
Pan Xiaojing, Marion Ken, Maram Jyotsna, Zhang Zhou Yuan, Francis Brian A, Nittala Muneeswar G, Sadda Srinivas R, Chopra Vikas
机构信息
*Doheny Image Reading Center, Doheny Eye Institute ‡Department of Ophthalmology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA †The Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shandong, P.R. China.
出版信息
J Glaucoma. 2015 Jun-Jul;24(5):e47-51. doi: 10.1097/IJG.0000000000000136.
PURPOSE
To investigate the reproducibility of anterior segment angle (ACA) metrics measurements in normal subjects on Cirrus spectral domain optical coherence tomography (SD-OCT).
METHODS
40 eyes from 20 healthy, normal subjects underwent anterior segment imaging using a Cirrus SD-OCT. For each eye, 2 acquisitions of 5-line raster scans were performed perpendicularly on the inferior (270 degrees) angle. The Schwalbe's line-angle opening distance (SL-AOD) and Schwalbe's line-trabecular-iris space area (SL-TISA) measurements were performed by masked certified reading center graders using customized grading software. Intra-acquisition, intergrader, and intragrader reproducibility of SL-AOD and SL-TISA measurements were evaluated by intraclass correlation coefficients (ICC), Bland-Altman plots, and computation of mean percent difference (MPD) and coefficient of variability (CV).
RESULTS
The mean SL-AOD (average of 2 acquisitions) was 0.75 mm (range, 0.32 mm to 1.39 mm); SL-TISA was 0.28 mm² (range, 0.082 mm² to 0.569 mm²). The repeatability of Cirrus SD-OCT was excellent for both SL-AOD (MPD 4.74%, CV=0.92, ICC=0.99) and SL-TISA (MPD 9.4%, CV=0.8, ICC=0.99). The intragrader reproducibility was high for SL-AOD (MPD 4.28%, CV=0.94, ICC=0.995) and SL-TISA (MPD 6.05%, CV=0.89, ICC=0.993). The inter-grader reproducibility was not as good but still excellent for both SL-AOD (MPD 15.47%, CV=0.95, ICC=0.94) and SL-TISA (MPD 19.43%, CV=0.99, ICC=0.93). Bland-Altman plots of all comparisons did not demonstrate any apparent bias, with similar repeatability at various SL-AOD and SL-TISA values.
CONCLUSIONS
In our population of young healthy adults with normal eyes, there was excellent intra-acquisition, intragrader, and intergrader reproducibility for Schwalbe's line-based ACA metrics obtained from Cirrus SD-OCT images. These SD-OCT-derived measures may serve as reliable descriptors of angle morphometry for use in clinical trials and clinical practice.
目的
研究在Cirrus光谱域光学相干断层扫描（SD - OCT）上正常受试者眼前节角度（ACA）指标测量的可重复性。
方法
对20名健康正常受试者的40只眼使用Cirrus SD - OCT进行眼前节成像。对于每只眼，在下方（270度）角垂直进行2次5线光栅扫描采集。由经过认证的掩蔽阅读中心评分员使用定制的评分软件进行Schwalbe线 - 角度开放距离（SL - AOD）和Schwalbe线 - 小梁 - 虹膜间隙面积（SL - TISA）测量。通过组内相关系数（ICC）、Bland - Altman图以及平均百分比差异（MPD）和变异系数（CV）的计算来评估SL - AOD和SL - TISA测量的采集内、评分员间和评分员内的可重复性。
结果
平均SL - AOD（2次采集的平均值）为0.75毫米（范围为0.32毫米至1.39毫米）；SL - TISA为0.28平方毫米（范围为0.082平方毫米至0.569平方毫米）。Cirrus SD - OCT对于SL - AOD（MPD 4.74%，CV = 0.92，ICC = 0.99）和SL - TISA（MPD 9.4%，CV = 0.8，ICC = 0.99）的重复性都非常好。评分员内对于SL - AOD（MPD 4.28%，CV = 0.94，ICC = 0.995）和SL - TISA（MPD 6.05%，CV = 0.89，ICC = 0.993）的可重复性很高。评分员间的可重复性虽没那么好，但对于SL - AOD（MPD 15.47%，CV = 0.95，ICC = 0.94）和SL - TISA（MPD 19.43%，CV = 0.99，ICC = 0.93）仍非常好。所有比较的Bland - Altman图均未显示任何明显偏差，在不同的SL - AOD和SL - TISA值下具有相似的重复性。
结论
在我们这群眼睛正常的年轻健康成年人中，从Cirrus SD - OCT图像获得的基于Schwalbe线的ACA指标在采集内、评分员内和评分员间具有出色的可重复性。这些源自SD - OCT的测量方法可作为用于临床试验和临床实践的可靠的房角形态描述指标。
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