Xu Benjamin Y, Israelsen Paul, Pan Billy X, Wang Dandan, Jiang Xuejuan, Varma Rohit
Roski Eye Institute, Keck School of Medicine at the University of Southern California Los Angeles, Los Angeles, California, United States.
Keck School of Medicine at the University of Southern California Los Angeles, Los Angeles, California, United States.
Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6313-6319. doi: 10.1167/iovs.16-19755.
The purpose of this study was to evaluate the benefit of analyzing an increased number of anterior segment optical coherence tomography (AS-OCT) images on measurement values of various anterior segment parameters.
Subjects for this cross-sectional study were recruited from the Chinese American Eye Study (CHES), a population-based study in Los Angeles, CA. Thirty-two AS-OCT images were acquired from one eye each of 83 consecutive subjects. Sixteen parameters were analyzed in each image, including angle opening distance (AOD), angle recess area (ARA), trabecular iris space area (TISA), trabecular iris angle (TIA), scleral spur angle (SSAngle), lens vault (LV), pupillary diameter (PD), anterior chamber depth (ACD), anterior chamber width (ACW), iris area (IA), and anterior chamber area (ACA). Data from 1, 2, 4, 8, 16, or 32 OCT images were averaged across subjects to calculate the range and mean of measurement values for each parameter.
Anatomical variations were poorly captured with fewer OCT images for AOD, ARA, TISA, SSAngle, IA, and LV. For these parameters, the range and mean of measurement values obtained from one OCT image deviated from 32-image values by up to 43.9% and 13.3% of the 32-image mean, respectively. These deviations decreased when additional OCT images were analyzed. Deviations from 32-image range and mean values were less pronounced regardless of image number for PD, ACD, ACW, and ACA, measuring up to 3.5% and 5.0%, respectively.
A multi-image approach should be the standard in OCT-based studies of AOD, ARA, TISA, TIA, SSAngle, IA, and LV.
本研究旨在评估分析更多数量的眼前节光学相干断层扫描（AS-OCT）图像对各种眼前节参数测量值的益处。
本横断面研究的受试者来自加利福尼亚州洛杉矶的基于人群的华裔美国人眼研究（CHES）。连续83名受试者的每只眼睛均采集32张AS-OCT图像。每张图像分析16个参数，包括房角开放距离（AOD）、房角隐窝面积（ARA）、小梁虹膜间隙面积（TISA）、小梁虹膜角（TIA）、巩膜突角（SSAngle）、晶状体拱高（LV）、瞳孔直径（PD）、前房深度（ACD）、前房宽度（ACW）、虹膜面积（IA）和前房面积（ACA）。对1、2、4、8、16或32张OCT图像的数据进行受试者间平均，以计算每个参数测量值的范围和平均值。
对于AOD、ARA、TISA、SSAngle、IA和LV，较少的OCT图像难以捕捉解剖变异。对于这些参数，从一张OCT图像获得的测量值范围和平均值分别比32张图像的值偏离32张图像平均值的43.9%和13.3%。分析额外的OCT图像时，这些偏差会减小。对于PD、ACD、ACW和ACA，无论图像数量如何，与32张图像范围和平均值的偏差均不太明显，分别高达3.5%和5.0%。
在基于OCT的AOD、ARA、TISA、TIA、SSAngle、IA和LV研究中，多图像方法应成为标准。
