心脏干细胞龛
Cardiac stem cell niches.
作者信息
Leri Annarosa, Rota Marcello, Hosoda Toru, Goichberg Polina, Anversa Piero
机构信息
Departments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Departments of Anesthesia and Medicine, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Stem Cell Res. 2014 Nov;13(3 Pt B):631-46. doi: 10.1016/j.scr.2014.09.001. Epub 2014 Sep 8.
Abstract
The critical role that stem cell niches have in cardiac homeostasis and myocardial repair following injury is the focus of this review. Cardiac niches represent specialized microdomains where the quiescent and activated state of resident stem cells is regulated. Alterations in niche function with aging and cardiac diseases result in abnormal sites of cardiomyogenesis and inadequate myocyte formation. The relevance of Notch1 signaling, gap-junction formation, HIF-1α and metabolic state in the regulation of stem cell growth and differentiation within the cardiac niches are discussed.
摘要
干细胞微环境在心脏稳态及损伤后心肌修复中所起的关键作用是本综述的重点。心脏微环境代表着特定的微结构域，其中驻留干细胞的静止和激活状态受到调控。随着衰老和心脏疾病，微环境功能的改变会导致心肌生成部位异常以及心肌细胞形成不足。本文讨论了Notch1信号传导、缝隙连接形成、HIF-1α和代谢状态在心脏微环境内干细胞生长和分化调控中的相关性。
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