绘制当前研究图谱并确定心血管疾病间充质干细胞的热点。

BACKGROUND: Mesenchymal stem cells (MSCs) have important research value and broad application prospects in the cardiovascular disease. This study provides information on the latest progress, evolutionary path, frontier research hotspots, and future research developmental trends in this field. METHODS: A knowledge map was generated by CiteSpace and VOSviewer analysis software based on data obtained from the literature on MSCs in the cardiovascular field. RESULTS: The USA and China ranked at the top in terms of the percentage of articles, accounting for 34.306% and 28.550%, respectively. The institution with the highest number of research publications in this field was the University of Miami, followed by the Chinese Academy of Medical Sciences and Harvard University. The research institution with the highest ACI value was Harvard University, followed by the Mayo Clinic and the University of Cincinnati. The top three subjects in terms of the number of published articles were cell biology, cardiovascular system cardiology, and research experimental medicine. The journal with the most publications in this field was Circulation Research, followed by Scientific Reports and Biomaterials. The direction of research on MSCs in the cardiovascular system was divided into four parts: (1) tissue engineering, scaffolds, and extracellular matrix research; (2) cell transplantation, differentiation, proliferation, and signal transduction pathway research; (3) assessment of the efficacy of stem cells from different sources and administration methods in the treatment of acute myocardial infarction, myocardial hypertrophy, and heart failure; and (4) exosomes and extracellular vesicles research. Tissue research is the hotspot and frontier in this field. CONCLUSION: MSC research has presented a gradual upward trend in the cardiovascular field. Multidisciplinary intersection is a characteristic of this field. Engineering and materials disciplines are particularly valued and have received attention from researchers. The progress in multidisciplinary research will provide motivation and technical support for the development of this field.

背景：间充质干细胞（MSCs）在心血管疾病领域具有重要的研究价值和广泛的应用前景。本研究提供了该领域 MSCs 最新进展、演进路径、前沿研究热点和未来研究发展趋势的信息。

方法：使用 CiteSpace 和 VOSviewer 分析软件，基于心血管领域 MSCs 文献数据生成知识图谱。

结果：美国和中国在发文比例方面位居前列，分别占 34.306%和 28.550%。该领域发文量最高的机构是迈阿密大学，其次是中国医学科学院和哈佛大学。研究机构 ACI 值最高的是哈佛大学，其次是梅奥诊所和辛辛那提大学。发文量最高的前三个主题是细胞生物学、心血管系统心脏病学和研究实验医学。该领域发文量最高的期刊是《Circulation Research》，其次是《Scientific Reports》和《Biomaterials》。心血管系统 MSCs 的研究方向分为四部分：（1）组织工程、支架和细胞外基质研究；（2）细胞移植、分化、增殖和信号转导途径研究；（3）评估不同来源和给药方式的干细胞在急性心肌梗死、心肌肥厚和心力衰竭治疗中的疗效；（4）外泌体和细胞外囊泡研究。组织研究是该领域的热点和前沿。

结论：MSC 在心血管领域的研究呈逐渐上升趋势。多学科交叉是该领域的一个特点。工程和材料学科受到特别重视，并引起了研究人员的关注。多学科研究的进展将为该领域的发展提供动力和技术支持。