高迁移率族蛋白B1（HMGB1）表达在结直肠癌患者中的预后意义
Prognostic significance of high mobility group box 1 (HMGB1) expression in patients with colorectal cancer.
作者信息
Ueda Masami, Takahashi Yusuke, Shinden Yoshiaki, Sakimura Shotaro, Hirata Hidenari, Uchi Ryutaro, Takano Yuki, Kurashige Junji, Iguchi Tomohiro, Eguchi Hidetoshi, Sugimachi Keishi, Yamamoto Hirofumi, Doki Yuichiro, Mori Masaki, Mimori Koshi
机构信息
Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
出版信息
Anticancer Res. 2014 Oct;34(10):5357-62.
BACKGROUND
High mobility group 1 (HMGB1) is a highly conserved non-histone nucleosomal protein in mammals. We investigated the clinical significance of HMGB1 expression in colorectal cancer (CRC).
PATIENTS AND METHODS
The expression of HMGB1 mRNA in 140 tumor and normal tissues from CRC patients was examined by quantitative real-time polymerase chain reaction (PCR). We immunohistochemically investigated HMGB1 expression in tumor and metastatic lymph nodes in CRC.
RESULTS
HMGB1 expression was significantly higher in tumor than in normal tissues. High HMGB1 expression was associated with larger tumor volumes, higher rates of lymphatic invasion, more frequent lymph node metastases and poorer prognoses for overall survival. Multivariate analyses showed that HMGB1 expression was an independent prognostic indicator of overall survival. Immunocytochemical analysis revealed that HMGB1 was overexpressed in both CRC tissues and regional lymph node metastases.
CONCLUSION
Investigating HMGB1 expression may be a predictor of postoperative lymph node metastasis and prognosis in CRC.
背景
高迁移率族蛋白1（HMGB1）是哺乳动物中一种高度保守的非组蛋白核小体蛋白。我们研究了HMGB1表达在结直肠癌（CRC）中的临床意义。
患者和方法
采用定量实时聚合酶链反应（PCR）检测140例CRC患者肿瘤组织和正常组织中HMGB1 mRNA的表达。我们通过免疫组化研究了CRC肿瘤组织和转移淋巴结中HMGB1的表达。
结果
肿瘤组织中HMGB1的表达明显高于正常组织。HMGB1高表达与更大的肿瘤体积、更高的淋巴管侵犯率、更频繁的淋巴结转移以及总体生存预后较差相关。多因素分析表明，HMGB1表达是总体生存的独立预后指标。免疫细胞化学分析显示，HMGB1在CRC组织和区域淋巴结转移中均过度表达。
结论
检测HMGB1表达可能是CRC术后淋巴结转移和预后的一个预测指标。
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