Salgado Afonso S I, Zângaro Renato A, Parreira Rodolfo B, Kerppers Ivo I
Institute of Biomedical Engineering, Camilo Castelo Branco University, Unicastelo, S J dos Campos, São Paulo, 12247-004, Brazil,
Lasers Med Sci. 2015 Jan;30(1):339-46. doi: 10.1007/s10103-014-1669-2. Epub 2014 Oct 3.
During aging processes, there is a range of functional changes, where we can highlight the disease related to the central nervous system, such as Alzheimer disease and others forms of dementia. This study investigated the effects of transcranial light emitting diode (LED) on cerebral blood flow in healthy elderly women analyzed by transcranial Doppler ultrasound (TCD) of the right and left middle cerebral artery and basilar artery. Twenty-five noninstitutionalized elderly women (mean age 72 years old), with a cognitive status >24, were assessed using transcranial Doppler ultrasound on two separate occasions: pre-irradiation and post-transcranial LED therapy (TCLT). Prior to this, they answered two questionnaires: the perceived stress scale and the general health questionnaire. TCLT (627 nm, 70 mW/cm(2), 10 J/cm(2)) was performed at four points of the frontal and parietal region for 30 s each, totaling 120 s two times per week for 4 weeks. Paired t-test results showed that there was a significant improvement after TCLT with increase in the systolic and diastolic velocity of the left middle cerebral artery (25 and 30%, respectively) and basilar artery (up to 17 and 25%), as well as a decrease in the pulsatility index and resistance index values of the three cerebral arteries analyzed (p < 0.05). TCD parameters showed improvement in the blood flow on the arteries analyzed. TCLT promoted a blood and vasomotor behavior of the basilar and middle cerebral arteries in healthy elderly women.
在衰老过程中，会出现一系列功能变化，其中我们可以突出与中枢神经系统相关的疾病，如阿尔茨海默病和其他形式的痴呆症。本研究通过经颅多普勒超声（TCD）对健康老年女性左右大脑中动脉和基底动脉的脑血流量进行分析，研究经颅发光二极管（LED）的影响。25名非机构养老的老年女性（平均年龄72岁），认知状态>24，在两个不同时间点接受经颅多普勒超声评估：照射前和经颅LED治疗（TCLT）后。在此之前，她们回答了两份问卷：感知压力量表和一般健康问卷。TCLT（627纳米，70毫瓦/平方厘米，10焦耳/平方厘米）在额叶和顶叶区域的四个点进行，每次30秒，每周两次，共4周。配对t检验结果显示，TCLT后有显著改善，左大脑中动脉的收缩期和舒张期速度分别增加25%和30%，基底动脉分别增加17%和25%，同时分析的三条脑动脉的搏动指数和阻力指数值降低（p<0.05）。TCD参数显示所分析动脉的血流有所改善。TCLT促进了健康老年女性基底动脉和大脑中动脉的血液及血管舒缩行为。
