Pang Raina D, Farrahi Layla, Glazier Shannon, Sussman Steve, Leventhal Adam M
University of Southern California Keck School of Medicine, Department of Preventive Medicine, 2250 Alcazar Street, CSC 240, Los Angeles, CA 90033, USA.
University of Southern California Keck School of Medicine, Department of Preventive Medicine, 2250 Alcazar Street, CSC 240, Los Angeles, CA 90033, USA.
Drug Alcohol Depend. 2014 Nov 1;144:225-30. doi: 10.1016/j.drugalcdep.2014.09.771. Epub 2014 Sep 28.
Studies show depressive symptoms are associated with substance use in adolescents, but the mechanism underlying this association is still unclear. This study investigated negative urgency - the disposition to rash action during emotional states - as a factor explaining relations between depressive symptoms and use of several substances.
In this cross-sectional study, 476 adolescents (mean age 14.5 years) completed self-report surveys. Regression models and products of coefficient analyses examined the overall relation of depressive symptoms to substance use and negative urgency as a statistical mediator of this association.
Depression levels associated with increased likelihood of lifetime use of cigarettes, other forms of tobacco, marijuana, alcohol, inhalants, prescription painkillers, and any substance. Relations between depression levels and lifetime use of alcohol, inhalants, and any substance were accounted for (i.e., statistically mediated) by negative urgency. In adolescents endorsing lifetime use, depression levels associated with younger age of first use of other forms of tobacco and alcohol as well as use frequency of cigarette, alcohol, and composite frequency. Negative urgency accounted for the covariance between depression level and age of first use of alcohol, but did not for other forms of tobacco or frequency of use of any substances.
Depression levels are associated with lifetime use of a variety of substances in early adolescence and targeting this risk factor with preventive efforts may be useful in reducing risk. Negative urgency may be an important target for interventions aimed at alcohol and inhalant use.
研究表明，抑郁症状与青少年的物质使用有关，但这种关联背后的机制仍不清楚。本研究调查了消极紧迫性——情绪状态下的 rash 行动倾向——作为解释抑郁症状与多种物质使用之间关系的一个因素。
在这项横断面研究中，476 名青少年（平均年龄 14.5 岁）完成了自我报告调查。回归模型和系数分析的乘积检验了抑郁症状与物质使用之间的总体关系，以及消极紧迫性作为这种关联的统计中介。
抑郁水平与终生使用香烟、其他形式烟草、大麻、酒精、吸入剂、处方止痛药及任何物质的可能性增加有关。消极紧迫性解释了抑郁水平与终生使用酒精、吸入剂及任何物质之间的关系（即，具有统计中介作用）。在认可终生使用的青少年中，抑郁水平与首次使用其他形式烟草和酒精的年龄较小以及香烟、酒精的使用频率和综合频率有关。消极紧迫性解释了抑郁水平与首次使用酒精年龄之间的协方差，但不能解释其他形式烟草或任何物质使用频率之间的协方差。
抑郁水平与青春期早期多种物质的终生使用有关，针对这一危险因素进行预防努力可能有助于降低风险。消极紧迫性可能是针对酒精和吸入剂使用的干预措施的一个重要目标。
