Han Shuwen, Chen Yan, Hu Jie, Ji Zhaoning
Department of Oncology, Wannan Medical College, Wuhu, Anhui Province, China.
Department of Oncology, Wannan Medical College, Wuhu, Anhui Province, China.
Microb Pathog. 2014 Dec;77:1-6. doi: 10.1016/j.micpath.2014.10.003. Epub 2014 Oct 2.
Tongue diagnosis, as a unique method of traditional Chinese medicine (TCM), discriminates physiological functions and pathological conditions by observing the changes of the tongue coating.
To evaluate the differences of tongue images and tongue coating microbiome between patients with colorectal cancer and healthy people.
The tongue diagnostic information acquisition system was used to photograph the tongue images and analyze the thickness of the tongue coatings in patients with colorectal cancer and healthy people. The next-generation sequencing technology was used to determine the V2-V4 hypervariable region of 16S rDNA to investigate the microbial community structure and diversity on the tongue coating.
The tongue coatings in patients with colorectal cancer were obvious thickening compared with tongue images in healthy people. The microbial community structure on the tongue coating was different between patients with colorectal cancer and healthy people.
Tongue diagnosis may provide important leads towards novel microbiome-related diagnostic tools and tongue coating microbiome may be a novel biomarker for characterizing patient with colorectal cancer.
舌诊作为中医独特的诊断方法，通过观察舌苔变化辨别生理功能和病理状况。
评估结直肠癌患者与健康人舌象及舌苔微生物群的差异。
采用舌诊信息采集系统拍摄结直肠癌患者和健康人的舌象并分析舌苔厚度。运用新一代测序技术测定16S rDNA的V2-V4高变区，以研究舌苔上的微生物群落结构和多样性。
与健康人的舌象相比，结直肠癌患者的舌苔明显增厚。结直肠癌患者与健康人的舌苔微生物群落结构不同。
舌诊可能为新型微生物群相关诊断工具提供重要线索，舌苔微生物群可能是结直肠癌患者特征化的新型生物标志物。
