Riley E M, Jobe O, Blackman M, Whittle H C, Greenwood B M
Medical Research Council Laboratories, Fajara, Near Banjul, The Gambia.
Infect Immun. 1989 Oct;57(10):3181-8. doi: 10.1128/iai.57.10.3181-3188.1989.
Cellular immune responses to malaria antigens are suppressed during acute Plasmodium falciparum infection, and evidence from both murine and human studies suggests that parasite-derived factors may be directly immunosuppressive. In this study we have shown that P. falciparum schizont sonic extract will suppress in vitro lymphoproliferative responses to purified malaria antigens and other soluble antigens. The degree of suppression appears to correlate with the level of the lymphoproliferative response to the schizont preparation and is correspondingly more marked in malaria-immune donors than in nonimmune individuals. The effect can be transferred with primed mononuclear cells and is partially abrogated by removal of CD8+ lymphocytes. The suppressive component of the schizont preparation is nondialyzable and partially heat labile and comigrates with hemoglobin-derived proteins in the molecular mass range 10 to 20 kilodaltons.
在急性恶性疟原虫感染期间，机体对疟疾抗原的细胞免疫反应受到抑制，来自小鼠和人类研究的证据表明，寄生虫衍生因子可能具有直接免疫抑制作用。在本研究中，我们发现恶性疟原虫裂殖体超声提取物会抑制对纯化疟疾抗原和其他可溶性抗原的体外淋巴细胞增殖反应。抑制程度似乎与对裂殖体制剂的淋巴细胞增殖反应水平相关，相应地，在疟疾免疫供体中比在非免疫个体中更明显。这种效应可以通过致敏单核细胞传递，并且通过去除CD8 + 淋巴细胞可部分消除。裂殖体制剂的抑制成分不可透析，部分对热不稳定，并且与分子量范围为10至20千道尔顿的血红蛋白衍生蛋白一起迁移。
