Theander T G, Svenson M, Bygbjerg I C, Kharazmi A, Jepsen S, Andersen B J, Larsen P B
Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Acta Pathol Microbiol Immunol Scand C. 1987 Dec;95(6):257-63. doi: 10.1111/j.1699-0463.1987.tb00039.x.
Malaria infection has been shown to induce alterations in immune reactivity. This report describes the effect of serum obtained from Plasmodium falciparum infected patients on in vitro proliferation of human blood mononuclear cells (BMNC) isolated from healthy individuals. Serum obtained before initiation of treatment suppressed the in vitro lymphocyte proliferative response to both Plasmodium-derived antigens and an unrelated antigen (PPD-tuberculin). The suppressive effect was lost if the serum was incubated at 56 degrees C for 30 min, and the effect was not HLA-restricted since the inhibition was seen on both autologous and heterologous BMNC. The degree of suppression was not correlated to the duration of the disease, the degree of parasitemia, or the use of chemoprophylaxis. Sera from 7 patients before and from 3 patients 30 days after initiation of treatment were pooled and fractionated. It was found that the strongest suppressive activity was in the serum fraction containing molecules from 30-100 kD.
疟疾感染已被证明会引起免疫反应性的改变。本报告描述了从恶性疟原虫感染患者获得的血清对从健康个体分离的人血单核细胞（BMNC）体外增殖的影响。治疗开始前获得的血清抑制了体外淋巴细胞对疟原虫衍生抗原和无关抗原（PPD-结核菌素）的增殖反应。如果血清在56℃孵育30分钟，抑制作用就会消失，并且这种作用不受HLA限制，因为在自体和异体BMNC上均可见抑制作用。抑制程度与疾病持续时间、寄生虫血症程度或化学预防的使用无关。收集了7例患者治疗前以及3例患者治疗开始30天后的血清并进行分级分离。发现最强的抑制活性存在于含有30-100kD分子的血清组分中。
