Jefferis Joanna Mary, Taylor John-Paul, Clarke Michael Patrick
Clinical Ageing Research Unit, Newcastle University, Newcastle upon Tyne, UK.
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.
Br J Ophthalmol. 2015 Mar;99(3):412-7. doi: 10.1136/bjophthalmol-2014-305657. Epub 2014 Oct 6.
BACKGROUND/AIMS: To assess the impact of impaired cognition on visual outcomes 1 year following cataract surgery in a cohort of older people.
Participants aged 75 years or more with bilateral cataract and scheduled for cataract surgery were recruited consecutively. Cognition was assessed using the revised Addenbrooke's cognitive examination (ACE-R). Participants were divided into two groups: normal (ACE-R ≥88) and impaired cognition (ACE-R <88). Visual quality of life (VQOL) and logarithm of minimum angle of resolution visual acuity (VA) were assessed at baseline and 1 year following cataract surgery.
Of 112 participants, 48 (43%) had normal cognition and 64 (57%) had impaired cognition. One year following cataract surgery participants in both groups had significant improvements in VQOL and VA. Visual outcomes at 1 year were significantly better in participants with normal cognition than in those with impaired cognition (95% CIs for difference 0.4-7.0 and 0.02-0.1, for VQOL and VA, respectively). Regression analyses correcting for potential confounders showed a relationship between baseline cognition and VA at 1 year (R(2)=0.30, p=0.001) and a possible relationship between baseline cognition and VQOL at 1 year (R(2)=0.41, p=0.01, this became insignificant after removal of outliers).
Patients with impaired cognition benefit from cataract surgery, but not to the same extent as patients with normal cognition.
背景/目的:评估认知功能受损对一组老年人白内障手术后1年视力预后的影响。
连续招募年龄在75岁及以上、患有双侧白内障且计划接受白内障手术的参与者。使用修订版的Addenbrooke认知检查(ACE-R)评估认知功能。参与者分为两组:认知正常(ACE-R≥88)和认知受损(ACE-R<88)。在基线和白内障手术后1年评估视觉生活质量(VQOL)和最小分辨角对数视力(VA)。
112名参与者中,48名(43%)认知正常,64名(57%)认知受损。白内障手术后1年,两组参与者的VQOL和VA均有显著改善。认知正常的参与者1年时的视力预后显著优于认知受损的参与者(VQOL和VA差异的95%CI分别为0.4 - 7.0和0.02 - 0.1)。校正潜在混杂因素的回归分析显示,基线认知与1年时的VA之间存在关联(R² = 0.30,p = 0.001),且基线认知与1年时的VQOL之间可能存在关联(R² = 0.41,p = 0.01,去除异常值后该关联变得不显著)。
认知受损的患者从白内障手术中获益,但程度不如认知正常的患者。