产金属β-内酰胺酶的拟杆菌物种可保护肠道微生物群的其他成员免受抗生素影响。
Metallo-β-lactamase-producing bacteroides species can shield other members of the gut microbiota from antibiotics.
作者信息
Stiefel Usha, Tima Mary Ann, Nerandzic Michelle M
机构信息
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
出版信息
Antimicrob Agents Chemother. 2015 Jan;59(1):650-3. doi: 10.1128/AAC.03719-14. Epub 2014 Oct 6.
Abstract
Antibiotics disrupt the intestinal microbiota, rendering patients vulnerable to colonization by exogenous pathogens. Intermicrobial interactions may attenuate this effect. Incubation with ceftriaxone-resistant, ccrA-positive, β-lactamase-producing Bacteroides strains raised the minimum bactericidal concentration of ceftriaxone required to kill a susceptible Escherichia coli strain (mean change, <0.25 to 29 mg/liter; P = 0.009); incubation with ceftriaxone-resistant but non-β-lactamase-producing Bacteroides strains had no effect. The production of β-lactamase by common members of the intestinal microbiota (Bacteroides) can protect susceptible fellow commensals from β-lactams.
摘要
抗生素会破坏肠道微生物群，使患者易受外源性病原体的定植。微生物间的相互作用可能会减弱这种影响。与对头孢曲松耐药、ccrA阳性、产β-内酰胺酶的拟杆菌菌株共同培养，提高了杀死敏感大肠杆菌菌株所需的头孢曲松最低杀菌浓度（平均变化，<0.25至29毫克/升；P = 0.009）；与对头孢曲松耐药但不产β-内酰胺酶的拟杆菌菌株共同培养则没有效果。肠道微生物群的常见成员（拟杆菌）产生的β-内酰胺酶可保护易受影响的共生菌免受β-内酰胺类药物的侵害。
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