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本文引用的文献

1
Toremifene in the treatment of breast cancer.托瑞米芬治疗乳腺癌。
World J Clin Oncol. 2014 Aug 10;5(3):393-405. doi: 10.5306/wjco.v5.i3.393.
2
Plant-derived decapeptide OSIP108 interferes with Candida albicans biofilm formation without affecting cell viability.植物源十肽OSIP108可干扰白色念珠菌生物膜的形成，而不影响细胞活力。
Antimicrob Agents Chemother. 2014 May;58(5):2647-56. doi: 10.1128/AAC.01274-13. Epub 2014 Feb 24.
3
Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo.雌激素受体拮抗剂是一类抗隐球菌药物，可直接结合EF手蛋白，并在体内与氟康唑协同作用。
mBio. 2014 Feb 11;5(1):e00765-13. doi: 10.1128/mBio.00765-13.
4
Toremifene for breast cancer: a review of 20 years of data.枸橼酸托瑞米芬治疗乳腺癌：20 年数据回顾。
Clin Breast Cancer. 2014 Feb;14(1):1-9. doi: 10.1016/j.clbc.2013.10.014. Epub 2013 Oct 31.
5
Strength in numbers: antifungal strategies against fungal biofilms.众人拾柴火焰高：抗真菌生物膜的策略。
Int J Antimicrob Agents. 2014 Feb;43(2):114-20. doi: 10.1016/j.ijantimicag.2013.10.023. Epub 2013 Nov 25.
6
Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilms.将两性霉素 B 和卡泊芬净重新用于提高其对白色念珠菌生物膜的活性。
J Antimicrob Chemother. 2014 Apr;69(4):1035-44. doi: 10.1093/jac/dkt449. Epub 2013 Nov 27.
7
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection.美国食品和药物管理局批准的选择性雌激素受体调节剂可抑制埃博拉病毒感染。
Sci Transl Med. 2013 Jun 19;5(190):190ra79. doi: 10.1126/scitranslmed.3005471.
8
ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients.ESCMID*指南：2012 年念珠菌病的诊断和管理：非中性粒细胞减少成年患者。
Clin Microbiol Infect. 2012 Dec;18 Suppl 7:19-37. doi: 10.1111/1469-0691.12039.
9
The nonsteroidal antiinflammatory drug diclofenac potentiates the in vivo activity of caspofungin against Candida albicans biofilms.非甾体类抗炎药双氯芬酸增强了卡泊芬净对白色念珠菌生物膜的体内活性。
J Infect Dis. 2012 Dec 1;206(11):1790-7. doi: 10.1093/infdis/jis594. Epub 2012 Sep 14.
10
New-found fundamentals of bacterial persistence.新发现的细菌持久存在的基本原理。
Trends Microbiol. 2012 Dec;20(12):577-85. doi: 10.1016/j.tim.2012.08.009. Epub 2012 Sep 5.

口服广谱抗生物膜化合物托瑞米芬可抑制白色念珠菌和金黄色葡萄球菌在体内形成生物膜。

Oral administration of the broad-spectrum antibiofilm compound toremifene inhibits Candida albicans and Staphylococcus aureus biofilm formation in vivo.

作者信息

De Cremer Kaat, Delattin Nicolas, De Brucker Katrijn, Peeters Annelies, Kucharíková Soña, Gerits Evelien, Verstraeten Natalie, Michiels Jan, Van Dijck Patrick, Cammue Bruno P A, Thevissen Karin

机构信息

Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium Department of Plant Systems Biology, VIB, Ghent, Belgium.

Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium.

出版信息

Antimicrob Agents Chemother. 2014 Dec;58(12):7606-10. doi: 10.1128/AAC.03869-14. Epub 2014 Oct 6.

DOI:10.1128/AAC.03869-14
PMID:25288093
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4249581/
Abstract

We here report on the in vitro activity of toremifene to inhibit biofilm formation of different fungal and bacterial pathogens, including Candida albicans, Candida glabrata, Candida dubliniensis, Candida krusei, Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis. We validated the in vivo efficacy of orally administered toremifene against C. albicans and S. aureus biofilm formation in a rat subcutaneous catheter model. Combined, our results demonstrate the potential of toremifene as a broad-spectrum oral antibiofilm compound.

摘要

我们在此报告托瑞米芬抑制不同真菌和细菌病原体生物膜形成的体外活性，这些病原体包括白色念珠菌、光滑念珠菌、都柏林念珠菌、克柔念珠菌、铜绿假单胞菌、金黄色葡萄球菌和表皮葡萄球菌。我们在大鼠皮下导管模型中验证了口服托瑞米芬对白色念珠菌和金黄色葡萄球菌生物膜形成的体内疗效。综合来看，我们的结果表明托瑞米芬作为一种广谱口服抗生物膜化合物的潜力。