Bitar Khalil N, Zakhem Elie
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. ; Department of Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston-Salem, NC, USA. ; Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Winston-Salem, NC, USA.
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA. ; Department of Molecular Medicine and Translational Science, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Biomed Eng Comput Biol. 2014 May 8;6:13-20. doi: 10.4137/BECB.S10961. eCollection 2014.
There are numerous available biodegradable materials that can be used as scaffolds in regenerative medicine. Currently, there is a huge emphasis on the designing phase of the scaffolds. Materials can be designed to have different properties in order to match the specific application. Modifying scaffolds enhances their bioactivity and improves the regeneration capacity. Modifications of the scaffolds can be later characterized using several tissue engineering tools. In addition to the material, cell source is an important component of the regeneration process. Modified materials must be able to support survival and growth of different cell types. Together, cells and modified biomaterials contribute to the remodeling of the engineered tissue, which affects its performance. This review focuses on the recent advancements in the designs of the scaffolds including the physical and chemical modifications. The last part of this review also discusses designing processes that involve viability of cells.
有许多可用的可生物降解材料可作为再生医学中的支架。目前，支架的设计阶段受到极大重视。可以将材料设计成具有不同特性，以匹配特定应用。对支架进行改性可增强其生物活性并提高再生能力。支架的改性随后可使用多种组织工程工具进行表征。除了材料之外，细胞来源也是再生过程的重要组成部分。改性材料必须能够支持不同细胞类型的存活和生长。细胞和改性生物材料共同作用于工程组织的重塑，这会影响其性能。本综述重点关注支架设计的最新进展，包括物理和化学改性。本综述的最后一部分还讨论了涉及细胞活力的设计过程。
