组织工程学和再生医学在胃肠道中的应用。
Tissue engineering and regenerative medicine as applied to the gastrointestinal tract.
机构信息
Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27101, United States; Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Winston-Salem, NC 27101, United States.
出版信息
Curr Opin Biotechnol. 2013 Oct;24(5):909-15. doi: 10.1016/j.copbio.2013.03.021. Epub 2013 Apr 10.
Abstract
The gastrointestinal (GI) tract is a complex system characterized by multiple cell types with a determined architectural arrangement. Tissue engineering of the GI tract aims to reinstate the architecture and function of all structural layers. The key point for successful tissue regeneration includes the use of cells/biomaterials that elucidate minimal immune response after implantation. Different biomaterial choices and cell sources have been proposed to engineer the GI tract. This review summarizes the recent advances in bioengineering the GI tract with emphasis on cell sources and scaffolding biomaterials.
摘要
胃肠道（GI）是一个复杂的系统，其特征在于具有确定的结构排列的多种细胞类型。胃肠道的组织工程旨在恢复所有结构层的结构和功能。成功组织再生的关键要点包括使用在植入后阐明最小免疫反应的细胞/生物材料。已经提出了不同的生物材料选择和细胞来源来工程化胃肠道。本综述总结了生物工程胃肠道的最新进展，重点介绍了细胞来源和支架生物材料。
相似文献
1
Tissue engineering and regenerative medicine as applied to the gastrointestinal tract.组织工程学和再生医学在胃肠道中的应用。
Curr Opin Biotechnol. 2013 Oct;24(5):909-15. doi: 10.1016/j.copbio.2013.03.021. Epub 2013 Apr 10.
2
Bioengineering and regeneration of gastrointestinal tissue: where are we now and what comes next?胃肠道组织的生物工程与再生：我们现在在哪里，下一步是什么？
Expert Opin Biol Ther. 2019 Jun;19(6):527-537. doi: 10.1080/14712598.2019.1595579. Epub 2019 Mar 26.
3
Intestinal tissue engineering: current concepts and future vision of regenerative medicine in the gut.肠道组织工程：肠道再生医学的当前概念和未来展望。
Neurogastroenterol Motil. 2012 Jan;24(1):7-19. doi: 10.1111/j.1365-2982.2011.01843.x.
4
Is bioengineering a possibility in gastrointestinal disorders?生物工程在胃肠道疾病中是否可行？
Expert Rev Gastroenterol Hepatol. 2015;9(12):1463-5. doi: 10.1586/17474124.2015.1103178. Epub 2015 Nov 2.
5
Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine.去细胞细胞外基质：再生医学中具有广阔前景和挑战性的新型生物材料。
Biomaterials. 2022 Oct;289:121786. doi: 10.1016/j.biomaterials.2022.121786. Epub 2022 Sep 3.
6
Tissue engineering in the gut: developments in neuromusculature.肠道组织工程：神经肌肉组织的发展。
Gastroenterology. 2014 Jun;146(7):1614-24. doi: 10.1053/j.gastro.2014.03.044. Epub 2014 Mar 27.
7
Decellularized orthopaedic tissue-engineered grafts: biomaterial scaffolds synthesised by therapeutic cells.去细胞化的骨科组织工程移植物：治疗细胞合成的生物材料支架。
Biomater Sci. 2018 Oct 24;6(11):2798-2811. doi: 10.1039/c8bm00772a.
8
Glycomics: New Challenges and Opportunities in Regenerative Medicine.糖组学：再生医学中的新挑战与机遇
Chemistry. 2016 Sep 12;22(38):13380-8. doi: 10.1002/chem.201602156. Epub 2016 Jul 11.
9
Biologically active chitosan systems for tissue engineering and regenerative medicine.用于组织工程和再生医学的生物活性壳聚糖系统。
Curr Top Med Chem. 2008;8(4):354-64. doi: 10.2174/156802608783790974.
10
Recent development and biomedical applications of decellularized extracellular matrix biomaterials.脱细胞细胞外基质生物材料的最新发展及其在生物医学中的应用。
Mater Sci Eng C Mater Biol Appl. 2019 Nov;104:109942. doi: 10.1016/j.msec.2019.109942. Epub 2019 Jul 3.
引用本文的文献
1
Engineered Living Systems Based on Gelatin: Design, Manufacturing, and Applications.基于明胶的工程化生命系统：设计、制造与应用
Adv Mater. 2025 Jun;37(22):e2416260. doi: 10.1002/adma.202416260. Epub 2025 Feb 5.
2
Regenerative medicine technologies applied to transplant medicine. An update.应用于移植医学的再生医学技术。最新进展。
Front Bioeng Biotechnol. 2022 Sep 28;10:1015628. doi: 10.3389/fbioe.2022.1015628. eCollection 2022.
3
Development of Bio-artificial Esophageal Tissue Engineering Utilization for Circumferential Lesion Transplantation: A Narrative Review.生物人工食管组织工程的发展利用于环形病变移植：叙述性综述。
Iran J Med Sci. 2022 Sep;47(5):406-421. doi: 10.30476/IJMS.2021.89194.1991.
4
Tissue engineering of the gastrointestinal tract: the historic path to translation.胃肠道组织工程：从历史走向转化应用之路
J Biol Eng. 2022 Apr 4;16(1):9. doi: 10.1186/s13036-022-00289-6.
5
The extracellular matrix of the gastrointestinal tract: a regenerative medicine platform.胃肠道的细胞外基质：再生医学平台。
Nat Rev Gastroenterol Hepatol. 2017 Sep;14(9):540-552. doi: 10.1038/nrgastro.2017.76. Epub 2017 Jul 12.
6
Temporal and spatial analysis of enteric nervous system regeneration in the sea cucumber Holothuria glaberrima.光滑海参肠道神经系统再生的时空分析
Regeneration (Oxf). 2014 Aug 5;1(3):10-26. doi: 10.1002/reg2.15. eCollection 2014 Jun.
7
Biomaterials for hollow organ tissue engineering.用于中空器官组织工程的生物材料。
Fibrogenesis Tissue Repair. 2016 Mar 23;9:3. doi: 10.1186/s13069-016-0040-6. eCollection 2016.
8
Bioengineering functional human sphincteric and non-sphincteric gastrointestinal smooth muscle constructs.生物工程功能性人体括约肌和非括约肌胃肠道平滑肌构建体。
Methods. 2016 Apr 15;99:128-34. doi: 10.1016/j.ymeth.2015.08.014. Epub 2015 Aug 24.
9
Fabrication of Biomimetic Bone Tissue Using Mesenchymal Stem Cell-Derived Three-Dimensional Constructs Incorporating Endothelial Cells.利用包含内皮细胞的间充质干细胞衍生三维构建体制造仿生骨组织
PLoS One. 2015 Jun 5;10(6):e0129266. doi: 10.1371/journal.pone.0129266. eCollection 2015.
10
Design strategies of biodegradable scaffolds for tissue regeneration.用于组织再生的可生物降解支架的设计策略。
Biomed Eng Comput Biol. 2014 May 8;6:13-20. doi: 10.4137/BECB.S10961. eCollection 2014.
本文引用的文献
1
Segmental reversal of the small bowel can end permanent parenteral nutrition dependency: an experience of 38 adults with short bowel syndrome.小肠节段性反转术可结束永久性肠外营养依赖：38 例短肠综合征成人的经验。
Ann Surg. 2012 Nov;256(5):739-44; discussion 744-5. doi: 10.1097/SLA.0b013e31827387f5.
2
Fabrication of electrospun poly (lactide-co-glycolide)-fibrin multiscale scaffold for myocardial regeneration in vitro.静电纺丝聚（丙交酯-乙交酯）-纤维蛋白多尺度支架的构建及其在体外心肌再生中的应用。
Tissue Eng Part A. 2013 Apr;19(7-8):849-59. doi: 10.1089/ten.TEA.2012.0374. Epub 2012 Dec 13.
3
Tissue engineered esophagus by mesenchymal stem cell seeding for esophageal repair in a canine model.利用间质干细胞种植构建组织工程化食管修复犬的食管缺损
J Surg Res. 2013 Jun 1;182(1):40-8. doi: 10.1016/j.jss.2012.07.054. Epub 2012 Aug 17.
4
Amniotic fluid-derived stem cells as a cell source for bone tissue engineering.羊膜来源的干细胞作为骨组织工程的细胞来源。
Tissue Eng Part A. 2012 Dec;18(23-24):2518-27. doi: 10.1089/ten.tea.2011.0672. Epub 2012 Aug 14.
5
Effects of surface functionalization of PLGA membranes for guided bone regeneration on proliferation and behavior of osteoblasts.PLGA 膜表面功能化对引导骨再生中骨细胞增殖和行为的影响。
J Biomed Mater Res A. 2013 Jan;101(1):44-53. doi: 10.1002/jbm.a.34298. Epub 2012 Jul 14.
6
In vitro degradation of three-dimensional chitosan/apatite composite rods prepared via in situ precipitation.通过原位沉淀法制备的三维壳聚糖/磷灰石复合棒的体外降解。
Int J Biol Macromol. 2012 Dec;51(5):868-73. doi: 10.1016/j.ijbiomac.2012.07.008. Epub 2012 Jul 16.
7
Gastric electrical stimulation for the treatment of diabetic gastroparesis.胃电刺激治疗糖尿病胃轻瘫。
Diabetes Metab. 2012 Nov;38(5):393-402. doi: 10.1016/j.diabet.2012.05.001. Epub 2012 Jun 27.
8
Decellularized ovine esophageal mucosa for esophageal tissue engineering.用于食管组织工程的去细胞化绵羊食管黏膜
Technol Health Care. 2012;20(3):215-23. doi: 10.3233/THC-2012-0672.
9
Intestinal crypts reproducibly expand in culture.肠道隐窝在培养中可重复扩增。
J Surg Res. 2012 Nov;178(1):48-54. doi: 10.1016/j.jss.2012.03.037. Epub 2012 Apr 10.
10
Chitosan-based scaffolds for the support of smooth muscle constructs in intestinal tissue engineering.壳聚糖基支架在肠道组织工程中用于平滑肌构建物的支撑。
Biomaterials. 2012 Jun;33(19):4810-7. doi: 10.1016/j.biomaterials.2012.03.051. Epub 2012 Apr 5.
Zotero 插件