Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27101, United States; Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Winston-Salem, NC 27101, United States.
Curr Opin Biotechnol. 2013 Oct;24(5):909-15. doi: 10.1016/j.copbio.2013.03.021. Epub 2013 Apr 10.
The gastrointestinal (GI) tract is a complex system characterized by multiple cell types with a determined architectural arrangement. Tissue engineering of the GI tract aims to reinstate the architecture and function of all structural layers. The key point for successful tissue regeneration includes the use of cells/biomaterials that elucidate minimal immune response after implantation. Different biomaterial choices and cell sources have been proposed to engineer the GI tract. This review summarizes the recent advances in bioengineering the GI tract with emphasis on cell sources and scaffolding biomaterials.
胃肠道（GI）是一个复杂的系统，其特征在于具有确定的结构排列的多种细胞类型。胃肠道的组织工程旨在恢复所有结构层的结构和功能。成功组织再生的关键要点包括使用在植入后阐明最小免疫反应的细胞/生物材料。已经提出了不同的生物材料选择和细胞来源来工程化胃肠道。本综述总结了生物工程胃肠道的最新进展，重点介绍了细胞来源和支架生物材料。
