生长因子颗粒蛋白前体的表达水平上调与原发性干燥综合征的发展相关。
Upregulated expression level of the growth factor, progranulin, is associated with the development of primary Sjögren's syndrome.
作者信息
Zhang Ni, Yang Ning, Chen Qilin, Qiu Feng, Li Xingfu
机构信息
Department of Hematology, Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China.
Center for Oncology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.
出版信息
Exp Ther Med. 2014 Nov;8(5):1643-1647. doi: 10.3892/etm.2014.1981. Epub 2014 Sep 22.
The aim of the present study was to investigate the expression and effect of progranulin (PGRN) in patients with primary Sjögren's syndrome (pSS). In total, 26 newly diagnosed pSS patients and 26 healthy subjects were enrolled in this study. The serum levels of PGRN and the inflammatory factor, interleukin-6 (IL-6), were detected using ELISA. In addition, the mRNA expression levels of these molecules were detected by quantitative polymerase chain reaction. The serum levels of PGRN and IL-6 in the pSS patients increased significantly compared with the healthy controls (P<0.05). During the remission stages, the levels of PGRN and IL-6 were comparable to those of the healthy controls. The serum level of PGRN in the pSS patients was shown to correlate with that of IL-6 in the pre-treatment and post-treatment stages. PGRN was upregulated in the pSS patients, indicating a possible role of PGRN in the pathogenesis and development of pSS.
本研究的目的是调查颗粒前体蛋白（PGRN）在原发性干燥综合征（pSS）患者中的表达及作用。本研究共纳入26例新诊断的pSS患者和26名健康受试者。采用酶联免疫吸附测定法（ELISA）检测PGRN和炎性因子白细胞介素-6（IL-6）的血清水平。此外，通过定量聚合酶链反应检测这些分子的mRNA表达水平。与健康对照组相比，pSS患者的PGRN和IL-6血清水平显著升高（P<0.05）。在缓解期，PGRN和IL-6的水平与健康对照组相当。pSS患者治疗前和治疗后的血清PGRN水平与IL-6水平相关。pSS患者中PGRN上调，提示PGRN在pSS的发病机制和发展中可能发挥作用。
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