Ma Cong, Xu Feng, Xiao Yu-Dong, Paudel Ramchandra, Sun Yi, Xiao En-Hua
Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China.
Yinzhou People's Hospital, Ningbo, Zhejiang 315000, P.R. China.
Oncol Lett. 2014 Nov;8(5):2140-2144. doi: 10.3892/ol.2014.2503. Epub 2014 Sep 4.
The present study aimed to evaluate the radiological and pathological features of intracranial hemangiopericytoma, and improve the understanding of this tumor. A retrospective analysis of radiological and pathological features of five cases of intracranial hemangiopericytoma was conducted between 2006 and 2012 in the Second Xiangya Hospital of Central South University. A total of five cases (three males and two females; aged 37-60 years) were enrolled. Magnetic resonance imaging revealed that the lesions were lobulated with iso-intensity T1-weighted image signals and slightly long T2-weighted image signals. Cystic degeneration, necrosis and flow void were observed. The case with the lesion located under the tentorium cerebelli exhibited compression of the fourth ventricle with lateral ventricle dilatation hydrocephalus. In all cases, the solid section of the lesion was markedly enhanced following injection of the contrast agent, and intratumoral vessels were observed. No case exhibited the dural tail sign. Immunohistochemical examination revealed positive expression of cluster of differentiation 34(CD34), vimentin and CD99, and negative expression of epithelial membrane antigen, S100 and glial fibrillary acidic protein. Proliferating cell nuclear antigen Ki-67 immunohistochemical staining revealed that <5% of cells expressed Ki-67 in two cases and 5-10% of cells expressed Ki-67 in three cases. In conclusion, intracranial hemangiopericytoma exhibits certain distinctive characteristics in radiological examination, allowing for improved diagnosis. However, pathological examination is required for confirmation.
本研究旨在评估颅内血管外皮细胞瘤的影像学和病理学特征，以增进对该肿瘤的认识。2006年至2012年期间，在中南大学湘雅二医院对5例颅内血管外皮细胞瘤的影像学和病理学特征进行了回顾性分析。共纳入5例患者（3例男性，2例女性；年龄37 - 60岁）。磁共振成像显示，病变呈分叶状，T1加权像呈等信号，T2加权像呈稍长信号。观察到有囊性变、坏死及流空现象。病变位于小脑幕下的病例出现第四脑室受压伴侧脑室扩张性脑积水。所有病例病变的实性部分在注射造影剂后均有明显强化，并观察到肿瘤内血管。无一例出现脑膜尾征。免疫组化检查显示，分化簇34（CD34）、波形蛋白和CD99呈阳性表达，上皮膜抗原、S100和胶质纤维酸性蛋白呈阴性表达。增殖细胞核抗原Ki-67免疫组化染色显示，2例中<5%的细胞表达Ki-67，3例中5 - 10%的细胞表达Ki-67。总之，颅内血管外皮细胞瘤在影像学检查中表现出一定的独特特征，有助于提高诊断。然而，确诊仍需病理检查。
