用于检测T和B淋巴细胞免疫球蛋白的玫瑰花结试验。

Rosette tests for T and B lymphocyte immunoglobulin.

作者信息

Haegert D G

机构信息

Department of Pathology, Montreal General Hospital and McGill University Montreal, Canada.

出版信息

Immunol Today. 1981 Oct;2(10):200-4. doi: 10.1016/0167-5699(81)90072-4.

DOI:10.1016/0167-5699(81)90072-4

Abstract

B lymphocytes synthesize and then express in their surface membranes immunoglobulin (Ig) molecules which serve as antigen receptors. Although controversy surrounds the precise nature of antigen receptors in T lymphocytes, these receptor molecules react with certain anti-Ig reagents and are considered to be Ig-related. Antiglobulin rosette tests and in particular the mixed antiglobulin rosetting reaction (MARR) and the direct antiglobulin rosetting reaction (DARR) have special merit in demonstration of lymphocyte Ig and Ig-related surface determinants; these lest systems are reviewed and compared with more conventional direct binding methodology which uses free anti-Ig molecules to sensitize lymphocytess.

摘要

B淋巴细胞合成免疫球蛋白（Ig）分子，然后将其表达于细胞膜表面，这些分子作为抗原受体。尽管关于T淋巴细胞抗原受体的确切性质存在争议，但这些受体分子能与某些抗Ig试剂发生反应，被认为与Ig相关。抗球蛋白玫瑰花结试验，尤其是混合抗球蛋白玫瑰花结反应（MARR）和直接抗球蛋白玫瑰花结反应（DARR），在显示淋巴细胞Ig及Ig相关表面决定簇方面具有特殊价值；本文对这些试验系统进行了综述，并与使用游离抗Ig分子致敏淋巴细胞的更传统直接结合方法进行了比较。

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Rosette tests for T and B lymphocyte immunoglobulin.用于检测T和B淋巴细胞免疫球蛋白的玫瑰花结试验。

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