铜催化的炔丙基溴二氟乙酸酯的脱羧三氟甲基化反应
Copper-Catalyzed Decarboxylative Trifluoromethylation of Propargyl Bromodifluoroacetates.
作者信息
Ambler Brett R, Peddi Santosh, Altman Ryan A
机构信息
Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States.
Department of Pharmacy, Birla Institute of Technology & Science, Pilani - Hyderabad Campus, Jawahar Nagar, Shameerpet Mandal, Hyderabad, 500078 Andhra Pradesh, India.
出版信息
Synthesis (Stuttg). 2014 Jul 15;46(14):1938-1946. doi: 10.1055/s-0033-1339128.
Abstract
The development of efficient methods for accessing fluorinated functional groups is desirable. Herein, we report a two-step method that utilizes catalytic Cu for the decarboxylative trifluoromethylation of propargyl bromodifluoroacetates. This protocol affords a mixture of propargyl trifluoromethanes and trifluoromethyl allenes.
摘要
开发高效的引入氟化官能团的方法是很有必要的。在此，我们报道了一种两步法，该方法利用催化铜实现溴二氟乙酸炔丙酯的脱羧三氟甲基化反应。此方案可得到炔丙基三氟甲烷和三氟甲基丙二烯的混合物。
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