Siroos Bahaadin, Harirchian Mohammad Hossein
Department of Neurology, School of Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iran J Neurol. 2014 Apr 3;13(2):57-63.
Multiple sclerosis (MS) is the most common chronic autoimmune demyelinating disorder of the central nervous system (CNS) which preferentially involves young women in early child bearing age. Opposite to traditional view emphasized on discouraging female patients from enduring pregnancy, recent investigations showed that pregnancy-related physiological alterations, especially during the third trimester, reduce the annual relapse rate of multiple sclerosis up to 80% which is comparable with conventional disease modifying drugs. Nowadays, expert's viewpoint is that female patients should not be discouraged from having children. Nonetheless, who and when should be allowed to endure gestational period is a complex decision which should be taken for every patient individually. It necessitates that neurologists be aware of updated information regarding pregnancy-related fetal and maternal considerations in patients with MS. In this brief review, it was tried to discuss this topic according to available data and guideline-based recommendations.
多发性硬化症（MS）是中枢神经系统（CNS）最常见的慢性自身免疫性脱髓鞘疾病，主要累及育龄期早期的年轻女性。与传统观点强调不鼓励女性患者怀孕相反，最近的研究表明，与怀孕相关的生理变化，尤其是在妊娠晚期，可将多发性硬化症的年复发率降低多达80%，这与传统的疾病修正药物相当。如今，专家的观点是不应劝阻女性患者生育。然而，允许谁以及何时怀孕是一个复杂的决定，需要针对每个患者单独做出。这就要求神经科医生了解有关MS患者怀孕相关的胎儿和母体注意事项的最新信息。在这篇简短的综述中，我们试图根据现有数据和基于指南的建议来讨论这个话题。
