Yuan B, Teng J F
Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Genet Mol Res. 2014 Sep 26;13(3):7808-14. doi: 10.4238/2014.September.26.19.
We examined the association between the adiponectin receptor 2 gene and the risk of ischemic stroke. Polymerase chain reaction-restriction fragment length polymorphism was used to detect rs12342 genotypes of the adiponectin receptor 2 gene in 300 ischemic stroke patients and 320 age- and gender-matched healthy controls. In the patient group, the AA, GA, and GG genotype frequencies were 39.3, 42.7, and 18.0%, respectively. The A and G allele frequencies were 0.607 and 0.393, respectively. In the control group, the AA, GA, and GG genotype frequencies were 29.0, 51.7, and 19.3%, respectively. The A and G allele frequencies were 0.548 and 0.452, respectively. The AA genotype and A allele frequencies in the patient group were significantly higher than those in the control group (both P < 0.01). The risk of ischemic stroke in AA genotype carriers was 1.786-fold greater than that in GG genotype carriers (odds ratio = 1.786, 95% confidence interval: 1.432-2.775; P = 0.013). After adjusting for various confounding factors, the difference remained significant (odds ratio = 1.874, 95% confidence interval: 1.221-2.765; P = 0.012). The AA genotype and A allele of rs12342 in the adiponectin receptor 2 gene may increase the risk of ischemic stroke, particularly the risk of atherosclerosis cerebral infarction.
我们研究了脂联素受体2基因与缺血性中风风险之间的关联。采用聚合酶链反应-限制性片段长度多态性方法，检测了300例缺血性中风患者及320例年龄和性别匹配的健康对照者脂联素受体2基因的rs12342基因型。在患者组中，AA、GA和GG基因型频率分别为39.3%、42.7%和18.0%。A和G等位基因频率分别为0.607和0.393。在对照组中，AA、GA和GG基因型频率分别为29.0%、51.7%和19.3%。A和G等位基因频率分别为0.548和0.452。患者组的AA基因型和A等位基因频率显著高于对照组（均P<0.01）。AA基因型携带者发生缺血性中风的风险比GG基因型携带者高1.786倍（比值比=1.786，95%置信区间：1.432-2.775；P=0.013）。在对各种混杂因素进行校正后，差异仍然显著（比值比=1.874，95%置信区间：1.221-2.765；P=0.012）。脂联素受体2基因rs12342的AA基因型和A等位基因可能增加缺血性中风的风险，尤其是动脉粥样硬化性脑梗死的风险。
