2001 - 2010年中国广州某当地医院葡萄球菌菌株的耐药性调查
Antimicrobial resistance investigation on Staphylococcus strains in a local hospital in Guangzhou, China, 2001-2010.
作者信息
Deng Yang, Liu Junyan, Peters Brian M, Chen Lei, Miao Jian, Li Bing, Li Lin, Chen Dingqiang, Yu Guangchao, Xu Zhenbo, Shirtliff Mark E
机构信息
1 College of Light Industry and Food Sciences, South China University of Technology , Guangzhou, China .
出版信息
Microb Drug Resist. 2015 Feb;21(1):102-4. doi: 10.1089/mdr.2014.0117. Epub 2014 Oct 9.
Abstract
A retrospective study was conducted on 1,739 Staphylococcus isolates from the First Affiliated Hospital of Jinan University (FAHJU) in Guangzhou during 2001-2010. With the exception of teicoplanin and vancomycin, antimicrobial resistance was commonly observed among the isolates examined, with high resistance rates for β-lactamases (94.0% and 73.7% for penicillin and oxacillin) and resistance percentages for cefoxitin, chloramphenicol, ciprofloxacin, clindamycin, erythromycin, gentamicin, trimethoprim-sulfamethoxazole, and tetracycline ranging from 83.9% to 19.4%. Two hundred sixty-three of the 1,739 isolates were subjected to SCCmec typing and 42 to MLST, spaA, and coa typing. ST239-MRSA-III was prevalently identified along with one distinct coa type HIJKL and 2 spaA types (WGKAOMQ-t037 and WGKAQQ-t030). Class 1 integrons were commonly detected (31.6%), although none of the integron-positive MRSA strains had been isolated since 2009. The widespread detection of integron-based antimicrobial resistance determinants may further contribute to the emergence of superbugs.
摘要
对2001年至2010年期间从广州暨南大学附属第一医院（FAHJU）分离出的1739株葡萄球菌进行了一项回顾性研究。在所检测的分离株中，除替考拉宁和万古霉素外，普遍观察到抗菌药物耐药性，β-内酰胺酶的耐药率较高（青霉素和苯唑西林分别为94.0%和73.7%），头孢西丁、氯霉素、环丙沙星、克林霉素、红霉素、庆大霉素、甲氧苄啶-磺胺甲恶唑和四环素的耐药百分比在83.9%至19.4%之间。1739株分离株中的263株进行了SCCmec分型，42株进行了多位点序列分型（MLST）、spaA分型和coa分型。主要鉴定出ST239-MRSA-III，以及一种独特的coa HIJKL型和2种spaA型（WGKAOMQ-t037和WGKAQQ-t030）。虽然自2009年以来未分离出整合子阳性的耐甲氧西林金黄色葡萄球菌（MRSA）菌株，但1类整合子仍普遍检测到（31.6%）。基于整合子的抗菌药物耐药决定簇的广泛检测可能会进一步促使超级细菌的出现。
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