Kozakowski Jarosław, Jeske Wojciech, Zgliczyński Wojciech
Department of Endocrinology, Medical Centre of Postgraduate Education, Bielański Hospital, Warsaw, Poland.
Endokrynol Pol. 2014;65(5):371-6. doi: 10.5603/EP.2014.0051.
The aim of this study was to estimate serum fetuin-A levels in lean and obese women with polycystic ovary syndrome (PCOS) and to find possible relationships between fetuin-A, metabolic factors and androgens in these patients.
In 25 lean (18-38 years, BMI 17.5-25.0 kg/m2) and 15 obese women (20-41 years, BMI 28.1-53.2 kg/m2) with PCOS, anthropometric indices and body composition were measured. Fasting serum fetuin-A, adiponectin, leptin, glucose, lipids, hsCRP, insulin, androgens and SHGB levels were estimated.
There was no significant difference in serum fetuin-A levels between lean and obese patients: 0.54 ± 0.13 g/L and 0.60 ± 0.14 g/L, respectively. We noted a correlation between BMI and leptin levels (r = 0.88; p < 0.0001) and a nearly significant negative correlation between BMI and adiponectin levels (r = -0.53; p = 0.11) in all subjects. In lean patients, we found a correlation between fetuin-A levels and ALT activity (r = 0.44; p < 0.05). In all participants, fetuin-A correlated directly with DHEA-S levels (r = 0.44; p < 0.03).
Serum fetuin-A levels were similar in lean and obese women with PCOS. We found an association between fetuin-A levels and ALT activity in lean patients and between fetuin-A levels and DHEA-S in all women. The role of fetuin-A in the mechanisms of insulin resistance, and its potential impact on androgenic hormones production in women with PCOS, need to be tested in further studies.
本研究旨在评估患有多囊卵巢综合征（PCOS）的消瘦和肥胖女性的血清胎球蛋白-A水平，并探寻这些患者中胎球蛋白-A、代谢因素和雄激素之间的可能关系。
对25名患有PCOS的消瘦女性（年龄18 - 38岁，BMI 17.5 - 25.0 kg/m²）和15名肥胖女性（年龄20 - 41岁，BMI 28.1 - 53.2 kg/m²）测量人体测量指标和身体成分。检测空腹血清胎球蛋白-A、脂联素、瘦素、葡萄糖、血脂、高敏C反应蛋白、胰岛素、雄激素和性激素结合球蛋白水平。
消瘦和肥胖患者的血清胎球蛋白-A水平无显著差异，分别为0.54 ± 0.13 g/L和0.60 ± 0.14 g/L。我们注意到所有受试者中BMI与瘦素水平之间存在相关性（r = 0.88；p < 0.0001），BMI与脂联素水平之间存在近乎显著的负相关性（r = -0.53；p = 0.11）。在消瘦患者中，我们发现胎球蛋白-A水平与谷丙转氨酶（ALT）活性之间存在相关性（r = 0.44；p < 0.05）。在所有参与者中，胎球蛋白-A与硫酸脱氢表雄酮（DHEA-S）水平直接相关（r = 0.44；p < 0.03）。
患有PCOS的消瘦和肥胖女性的血清胎球蛋白-A水平相似。我们发现消瘦患者中胎球蛋白-A水平与ALT活性之间以及所有女性中胎球蛋白-A水平与DHEA-S之间存在关联。胎球蛋白-A在胰岛素抵抗机制中的作用及其对PCOS女性雄激素生成的潜在影响，需要在进一步研究中进行验证。
