Gurbuz Tugba, Alanya Tosun Sebnem, Cebi Aysegul, Gokmen Oya, Usta Murat
Department of Obstetrics and Gynaecology, Medistate Kavacik Hospital, Istanbul, TUR.
Department of Obstetrics and Gynaecology, Giresun University Faculty of Medicine, Giresun, TUR.
Cureus. 2021 Oct 6;13(10):e18553. doi: 10.7759/cureus.18553. eCollection 2021 Oct.
Introduction Polycystic ovary syndrome (PCOS) may have an increased risk for the development of systemic and metabolic pathogenesis such as cardiovascular diseases, insulin resistance (IR), diabetes mellitus (DM) and dyslipidemia. However, there is no reliable marker to show the relation. Fetuin-A is an adipokine whereas paraoxonase-1 (PON-1) is a high-density lipoprotein-linked enzyme to demonstrate oxidative stress. This study aimed to evaluate serum fetuin-A and PON-1 levels in infertile PCOS women based on body mass index (BMI). Methods A prospective case-control study in a university setting was designed. A total of 88 patients admitted to the Giresun University Faculty of Medicine Gynecology Clinic between February and April 2021 were included in the study. The subjects were divided as follows: PCOS-low-BMI (BMI≤25) vs. Controls-low-BMI (BMI≤25) and PCOS-high-BMI (BMI>25) vs. Controls-high-BMI (BMI>25). Those who had at least two criteria of the 2003 Rotterdam Consensus were diagnosed with PCOS. Serum fetuin-A and PON-1 levels were compared. Results The mean levels of fetuin-A were not significantly different in the groups (p=0.955). Serum PON-1 levels were lower in the PCOS group (109.1±61.4 vs. 140.1±80.0; p=0.040), but it lost significance with adjusted values for covariants as age and BMI. Although PON-1 was not significantly different in the PCOS group of BMI<25 kg/m subgroup, it was significantly lower in the PCOS group of BMI≥25 kg/m subgroup (p=0.820 vs. p=0.048). Conclusion Serum fetuin-A activity did not differ with PCOS. Serum PON-1 might be a promising and research-worthy marker, especially for obese PCOS patients.
多囊卵巢综合征（PCOS）可能会增加发生全身性和代谢性发病机制的风险，如心血管疾病、胰岛素抵抗（IR）、糖尿病（DM）和血脂异常。然而，尚无可靠的标志物来表明这种关系。胎球蛋白-A是一种脂肪因子，而对氧磷酶-1（PON-1）是一种与高密度脂蛋白相关的酶，可显示氧化应激。本研究旨在根据体重指数（BMI）评估不孕PCOS女性的血清胎球蛋白-A和PON-1水平。
设计了一项在大学环境中进行的前瞻性病例对照研究。2021年2月至4月期间，共有88名入住吉雷松大学医学院妇科诊所的患者纳入研究。受试者分为以下几组：PCOS-低BMI组（BMI≤25）与对照组-低BMI组（BMI≤25）以及PCOS-高BMI组（BMI>25）与对照组-高BMI组（BMI>25）。符合2003年鹿特丹共识中至少两项标准的患者被诊断为PCOS。比较血清胎球蛋白-A和PON-1水平。
各组胎球蛋白-A的平均水平无显著差异（p = 0.955）。PCOS组的血清PON-1水平较低（109.1±61.4 vs. 140.1±80.0；p = 0.040），但在对年龄和BMI等协变量进行校正后失去了显著性。虽然BMI<25 kg/m亚组的PCOS组中PON-1无显著差异，但BMI≥25 kg/m亚组的PCOS组中PON-1显著较低（p = 0.820 vs. p = 0.048）。
血清胎球蛋白-A活性在PCOS患者中无差异。血清PON-1可能是一个有前景且值得研究的标志物，尤其是对于肥胖的PCOS患者。
