Tong L X, Wu S, Li T, Qureshi A A, Giovannucci E L, Cho E
Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, U.S.A.
Department of Health Policy and Management, Harvard School of Public Health, Boston, MA, U.S.A.
Br J Dermatol. 2015;172(5):1316-22. doi: 10.1111/bjd.13463. Epub 2015 Feb 15.
Metabolic syndrome has been associated with both gallstones and psoriasis, suggesting a potential biological linkage between gallstones and psoriasis. However, the association between gallstones and psoriasis has not yet been studied.
To investigate the association between gallstones and psoriasis.
This was a prospective cohort study [Nurses' Health Study II (1991-2005)]. Women aged 25-42 years who were free from psoriasis at baseline and who responded to a 2005 follow-up questionnaire regarding their diagnosis of psoriasis were included (n = 89,230). The relative risk (RR) of developing psoriasis or psoriatic arthritis (PsA), which were self-reported and validated by supplemental questionnaires, was measured.
In this population, 2206 participants had gallstones confirmed by a history of cholecystectomy at baseline. A total of 642 individuals had a diagnosis of incident psoriasis, of whom 157 had concomitant PsA. After adjusting for known risk factors of psoriasis besides body mass index (BMI), a baseline history of cholecystectomy-confirmed gallstones was associated with increased risk of psoriasis [multivariate-adjusted RR 2·20, 95% confidence interval (CI) 1·56-3·10] and concomitant PsA (multivariate-adjusted RR 4·41, 95% CI 2·70-7·18). After additionally adjusting for BMI, the fully adjusted RRs associated with a history of cholecystectomy-confirmed gallstones were 1·70 (95% CI 1·20-2·41) for psoriasis and 2·96 (95% CI 1·80-4·89) for PsA.
Personal history of gallstones was associated with an increased risk of psoriasis and PsA, independent of obesity, in a cohort of U.S. women.
代谢综合征与胆结石和银屑病均有关联，提示胆结石与银屑病之间可能存在生物学联系。然而，胆结石与银屑病之间的关联尚未得到研究。
研究胆结石与银屑病之间的关联。
这是一项前瞻性队列研究[护士健康研究II（1991 - 2005年）]。纳入了25 - 42岁、基线时无银屑病且对2005年关于银屑病诊断的随访问卷作出回应的女性（n = 89,230）。测量了自我报告并经补充问卷验证的发生银屑病或银屑病关节炎（PsA）的相对风险（RR）。
在该人群中，2206名参与者在基线时经胆囊切除术病史确诊有胆结石。共有642人被诊断为新发银屑病，其中157人伴有PsA。在调整了除体重指数（BMI）外已知的银屑病风险因素后，经胆囊切除术确诊的胆结石基线病史与银屑病风险增加相关[多变量调整RR 2.20，9
