Jöhrer Karin, Ploner Christian, Thangavadivel Shanmugapriya, Wuggenig Philipp, Greil Richard
Tyrolean Cancer Research Institute , Innrain 66, 6020 Innsbruck , Austria
Expert Opin Biol Ther. 2015 Jan;15(1):61-77. doi: 10.1517/14712598.2015.970632. Epub 2014 Oct 11.
Adipocytes and their products play essential roles in tumor establishment and progression. As the main cellular component of the bone marrow, adipocytes may contribute to the development of hematologic tumors.
This review summarizes experimental data on adipocytes and their interaction with various cancer cells. Special focus is set on the interactions of bone marrow adipocytes and normal and transformed cells of the hematopoietic system such as myeloma and leukemia cells. Current in vitro and in vivo data are summarized and the potential of novel therapeutic targets is critically discussed.
Targeting lipid metabolism of cancer cells and adipocytes in combination with standard therapeutics might open novel therapeutic avenues in these cancer entities. Adipocyte-derived products such as free fatty acids and specific adipokines such as adiponectin may be vital anti-cancer targets in hematologic malignancies. However, available data on lipid metabolism is currently mostly referring to peripheral fat cell/cancer cell interactions and results need to be evaluated specifically for the bone marrow niche.
脂肪细胞及其产物在肿瘤的发生和发展中起着至关重要的作用。作为骨髓的主要细胞成分，脂肪细胞可能促进血液系统肿瘤的发展。
本综述总结了关于脂肪细胞及其与各种癌细胞相互作用的实验数据。特别关注骨髓脂肪细胞与造血系统正常细胞和转化细胞（如骨髓瘤细胞和白血病细胞）之间的相互作用。总结了当前的体外和体内数据，并对新型治疗靶点的潜力进行了批判性讨论。
将针对癌细胞和脂肪细胞脂质代谢的治疗与标准疗法相结合，可能为这些癌症实体开辟新的治疗途径。脂肪细胞衍生的产物如游离脂肪酸和特定的脂肪因子如脂联素，可能是血液系统恶性肿瘤重要的抗癌靶点。然而，目前关于脂质代谢的现有数据大多涉及外周脂肪细胞/癌细胞的相互作用，其结果需要针对骨髓微环境进行具体评估。
