Yoon Jung Hyun, Kim Eun-Kyung, Youk Ji Hyun, Moon Hee Jung, Kwak Jin Young
Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
Int J Endocrinol. 2014;2014:321595. doi: 10.1155/2014/321595. Epub 2014 Sep 18.
Background. To evaluate the role of ultrasonography (US), US-guided fine-needle aspiration (USFNA) and intraoperative frozen section (FS) in follicular neoplasm. Methods. US features, USFNA cytology, and FS results were compared based on the pathology results of patients with follicular adenoma (FA), follicular carcinoma (FC), and follicular variant of papillary thyroid carcinoma (FVPTC). Results. FC and FVPTC showed significantly higher rates of suspicious US features (P < 0.05) and positive findings on either US or cytology, 80.0% and 90.7%, compared to FA, 64.5% (P = 0.001). Intraoperative FS showed higher malignant rates in FVPTC and FC (81.8% and 75.0%, resp.), compared to FA (3.8%, P < 0.001). Conclusion. Suspicious US features were more significantly seen in FC and FVPTC compared to FA. Intraoperative FS is useful in the differential diagnosis of these lesions and supplements cytology results of USFNA.
背景。评估超声检查（US）、超声引导下细针穿刺活检（USFNA）及术中冰冻切片（FS）在滤泡性肿瘤中的作用。方法。基于滤泡性腺瘤（FA）、滤泡性癌（FC）及甲状腺乳头状癌滤泡亚型（FVPTC）患者的病理结果，比较其超声特征、USFNA细胞学检查结果及FS结果。结果。与FA的64.5%相比，FC和FVPTC的可疑超声特征发生率（P < 0.05）以及超声或细胞学检查的阳性发现率显著更高，分别为80.0%和90.7%（P = 0.001）。术中FS显示，FVPTC和FC的恶性率更高（分别为81.8%和75.0%），而FA的恶性率为3.8%（P < 0.001）。结论。与FA相比，FC和FVPTC中可疑超声特征更为显著。术中FS对这些病变的鉴别诊断有用，并可补充USFNA的细胞学检查结果。
