使用活载体开发疫苗
Development of Vaccines Using Live Vectors.
作者信息
Wang Shifeng, Curtiss Roy
机构信息
Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA ; School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA;
出版信息
Vaccines (Basel). 2014 Jan 7;2(1):49-88. doi: 10.3390/vaccines2010049.
Abstract
still causes severe morbidity and mortality worldwide, especially in young children and the elderly. Much effort has been dedicated to developing protein-based universal vaccines to conquer the current shortcomings of capsular vaccines and capsular conjugate vaccines, such as serotype replacement, limited coverage and high costs. A recombinant live vector vaccine delivering protective antigens is a promising way to achieve this goal. In this review, we discuss the researches using live recombinant vaccines, mainly live attenuated and lactic acid bacteria, to deliver pneumococcal antigens. We also discuss both the limitations and the future of these vaccines.
摘要
在全球范围内，它仍然会导致严重的发病率和死亡率，尤其是在幼儿和老年人中。人们付出了很多努力来研发基于蛋白质的通用疫苗，以克服目前荚膜疫苗和荚膜结合疫苗的缺点，如血清型替换、覆盖范围有限和成本高昂。递送保护性抗原的重组活载体疫苗是实现这一目标的一种有前途的方法。在这篇综述中，我们讨论了使用活重组疫苗（主要是减毒活疫苗和乳酸菌）递送肺炎球菌抗原的研究。我们还讨论了这些疫苗的局限性和未来发展。
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