VA Greater Los Angeles Healthcare System, Los Angeles, California, United States of America; University of California Los Angeles, Los Angeles, California, United States of America.
University of California Los Angeles, Los Angeles, California, United States of America.
PLoS One. 2014 Oct 13;9(10):e110007. doi: 10.1371/journal.pone.0110007. eCollection 2014.
Although motivational disturbances are common in schizophrenia, their neurophysiological and psychological basis is poorly understood. This electroencephalography (EEG) study examined the well-established motivational direction model of asymmetric frontal brain activity in schizophrenia. According to this model, relative left frontal activity in the resting EEG reflects enhanced approach motivation tendencies, whereas relative right frontal activity reflects enhanced withdrawal motivation tendencies. Twenty-five schizophrenia outpatients and 25 healthy controls completed resting EEG assessments of frontal asymmetry in the alpha frequency band (8-12 Hz), as well as a self-report measure of behavioral activation and inhibition system (BIS/BAS) sensitivity. Patients showed an atypical pattern of differences from controls. On the EEG measure patients failed to show the left lateralized activity that was present in controls, suggesting diminished approach motivation. On the self-report measure, patients reported higher BIS sensitivity than controls, which is typically interpreted as heightened withdrawal motivation. EEG asymmetry scores did not significantly correlate with BIS/BAS scores or with clinical symptom ratings among patients. The overall pattern suggests a motivational disturbance in schizophrenia characterized by elements of both diminished approach and elevated withdrawal tendencies.
虽然动机障碍在精神分裂症中很常见，但它们的神经生理和心理基础还了解甚少。这项脑电图（EEG）研究检验了精神分裂症中静止态大脑活动不对称的既定动机导向模型。根据该模型，休息时 EEG 中的相对左侧额区活动反映了增强的趋近动机倾向，而相对右侧额区活动反映了增强的回避动机倾向。25 名精神分裂症门诊患者和 25 名健康对照者完成了额区 alpha 频段（8-12Hz）不对称的静息脑电图评估，以及行为激活和抑制系统（BIS/BAS）敏感性的自我报告测量。患者与对照组的差异呈现出一种非典型模式。在 EEG 测量中，患者没有表现出对照组中存在的左侧偏向活动，这表明趋近动机减弱。在自我报告测量中，患者报告的 BIS 敏感性高于对照组，这通常被解释为回避动机增强。EEG 不对称评分与患者的 BIS/BAS 评分或临床症状评分均无显著相关性。总的来说，这表明精神分裂症存在一种动机障碍，其特点是趋近和回避倾向都有所减弱。
