Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Mol Nutr Food Res. 2015 Feb;59(2):315-22. doi: 10.1002/mnfr.201400333. Epub 2014 Nov 17.
Few data, with conflicting findings, are available linking red meat consumption to indicators of insulin resistance and endothelial dysfunction. This study aimed to investigate the association of red meat consumption with insulin resistance and endothelial dysfunction among a sample of female nurses in Isfahan, Iran.
This cross-sectional study was carried out among 420 female nurses who were selected by a multistage cluster random sampling method. Usual dietary intakes were assessed using a validated food frequency questionnaire. Red meat intake was calculated by summing up the consumption of all kinds of red meat in foods and processed meat in sausages and fast foods. To measure serum concentrations of adhesion molecules and glycemic indexes, a fasting blood sample was taken. After adjustment for potential confounders, high red meat intake was significantly associated with higher fasting plasma glucose, homeostasis model assessment of insulin resistance, and lower quantitative insulin sensitivity check index. Although high red meat intake was significantly associated with higher serum insulin levels and lower homeostasis model assessment of beta-cell function in the crude model, after controlling for BMI, the association was no longer significant. Red meat consumption was associated with high concentrations of E-selectin, soluble vascular cell adhesion molecule-1 (sVCAM-1), and soluble intercellular adhesion molecule-1 (sICAM-1) after adjustment for different potential confounders.
We found that increased red meat intake was associated with high concentrations of plasma endothelial dysfunction biomarkers and abnormal glucose homeostasis among Iranian women. Prospective studies are required to confirm these findings.
关于摄入红肉类与胰岛素抵抗和血管内皮功能障碍的相关指标之间的关系，目前仅有少量数据且结果相互矛盾。本研究旨在调查伊朗伊斯法罕的女性护士中，红肉类摄入与胰岛素抵抗和血管内皮功能障碍之间的关联。
这是一项横断面研究，共纳入了 420 名女性护士，采用多阶段聚类随机抽样方法进行选择。使用经过验证的食物频率问卷评估了习惯性饮食摄入量。通过将食物中各种红肉类和香肠及快餐中的加工肉类的摄入量相加来计算红肉类的摄入量。为了测量血清黏附分子和血糖指数，采集了空腹血样。在调整了潜在混杂因素后，高红肉类摄入与空腹血糖、胰岛素抵抗的稳态模型评估和定量胰岛素敏感性检查指数较低显著相关。虽然高红肉类摄入与空腹胰岛素水平升高和β细胞功能的稳态模型评估降低在粗模型中显著相关，但在控制 BMI 后，这种相关性不再显著。在调整了不同潜在混杂因素后，红肉类摄入与 E-选择素、可溶性血管细胞黏附分子-1（sVCAM-1）和可溶性细胞间黏附分子-1（sICAM-1）的高浓度相关。
我们发现，伊朗女性中，红肉类摄入增加与血浆内皮功能障碍生物标志物浓度升高和葡萄糖稳态异常有关。需要进行前瞻性研究来证实这些发现。
