Berger David, Postma Erik
Animal Ecology at Department of Ecology and Genetics, Evolutionary Biology Centre, Uppsala University, SE-75236 Uppsala, Sweden
Institute of Evolutionary Biology and Environmental Studies, University of Zurich, CH-8057 Zürich, Switzerland.
Genetics. 2014 Dec;198(4):1417-20. doi: 10.1534/genetics.114.169870. Epub 2014 Oct 13.
Empirical evidence for diminishing fitness returns of beneficial mutations supports Fisher's geometric model. We show that a similar pattern emerges through the phenomenon of regression to the mean and that few studies correct for it. Although biases are often small, regression to the mean has overemphasized diminishing returns and will hamper cross-study comparisons unless corrected for.
有益突变适应性回报递减的实证证据支持了费希尔几何模型。我们表明，通过均值回归现象也会出现类似模式，而且很少有研究对此进行校正。尽管偏差通常较小，但均值回归过度强调了回报递减，除非进行校正，否则将妨碍跨研究比较。
