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巴西东南部非人灵长类动物中米纳斯锥虫的高感染率。

High infection prevalences by Trypanosoma minasense in non-human primates from the Southeast region of Brazil.

作者信息

Machado-Silva Maria Paula, de Abreu Filipe Vieira Santos, Alves Fernanda Moreira, Aquino-Teixeira Sandy Micaele, de Oliveira Felipe, Dario Maria Augusta, das Chagas Xavier Samanta Cristina, Lourenço-de-Oliveira Ricardo, Roque André Luiz Rodrigues

机构信息

Laboratório de Biologia de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Laboratório de Comportamento de Insetos, Instituto Federal do Norte de Minas Gerais, Salinas, Brazil.

出版信息

Sci Rep. 2024 Dec 28;14(1):30669. doi: 10.1038/s41598-024-74235-5.

DOI:10.1038/s41598-024-74235-5
PMID:39730413
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11681205/
Abstract

Non-human primates (NHPs) are reported as exclusive hosts of Trypanosoma minasense, whose transmission cycle remains unknown. We investigated trypanosomatid infections in 194 NHPs of nine species from the Brazilian Southeast region. We evaluated the impact of landscape composition and forest fragmentation on T. minasense infection. In the Atlantic Forest areas, Sapajus nigritus presented a higher positivity for T. minasense on the blood slides (60.9%) compared to Callithrix spp. (24.6%) and Alouatta guariba clamitans (20.7%); molecular analysis revealed higher infection prevalences in S. nigritus (87.0%) and A. g. clamitans (78.8%) than Callithrix spp. (50.8%). Callithrix spp. from the Cerrado and bordering areas showed higher infection prevalences by T. minasense on the blood slides (51.8%) and molecular diagnosis (77.6%). Eight (7.8%) positive hemocultures were obtained, but in only one (from A. g. clamitans) parasites were isolated and characterized as Crithidia mellificae. Trypanosoma cruzi TcII and T. rangeli lineage A were identified in Leontopithecus rosalia and C. penicillata, respectively. The results indicate that Alouatta, Callithrix, and Sapajus genera are highly exposed to T. minasense in the study area and landscape analysis revealed that these infections were inversely correlated with the proportion of forest and directly correlated with the forest fragmentation.

摘要

据报道，非人灵长类动物（NHPs）是米纳斯锥虫（Trypanosoma minasense）的唯一宿主，其传播周期仍然未知。我们调查了巴西东南部地区9个物种的194只非人灵长类动物的锥虫感染情况。我们评估了景观组成和森林破碎化对米纳斯锥虫感染的影响。在大西洋森林地区，与狨属（Callithrix spp.）（24.6%）和黑吼猴（Alouatta guariba clamitans）（20.7%）相比，黑帽卷尾猴（Sapajus nigritus）在血涂片上米纳斯锥虫的阳性率更高（60.9%）；分子分析显示，黑帽卷尾猴（87.0%）和黑吼猴指名亚种（A. g. clamitans）（78.8%）的感染率高于狨属（50.8%）。来自塞拉多和接壤地区的狨属在血涂片上（51.8%）和分子诊断（77.6%）显示出更高的米纳斯锥虫感染率。获得了8份（7.8%）阳性血液培养物，但仅1份（来自黑吼猴指名亚种）分离出寄生虫并鉴定为蜜蜂克氏锥虫（Crithidia mellificae）。在金狮面狨（Leontopithecus rosalia）和巴拿马灵猫（C. penicillata）中分别鉴定出克氏锥虫TcII和兰氏锥虫（T. rangeli）谱系A。结果表明，在研究区域，蛛猴属（Alouatta）、狨属和卷尾猴属（Sapajus）高度暴露于米纳斯锥虫，景观分析显示这些感染与森林比例呈负相关，与森林破碎化呈正相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/11681205/484a0c3d69c4/41598_2024_74235_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/11681205/4fda8c73d993/41598_2024_74235_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/11681205/4fda8c73d993/41598_2024_74235_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/11681205/73d1417e8ce8/41598_2024_74235_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/485a/11681205/92ea4cfb80a7/41598_2024_74235_Fig3_HTML.jpg
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