Fischer Robert S
Cell Biology and Physiology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda MD, 20892
J Cell Biol. 2014 Oct 13;207(1):9-11. doi: 10.1083/jcb.201409059.
Polarized epithelial cells create tightly packed arrays of microvilli in their apical membrane, but the fate of these microvilli is relatively unknown when epithelial cell polarity is lost during wound healing. In this issue, Klingner et al. (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201402037) show that, when epithelial cells become subconfluent, actomyosin contractions locally within the apical cortex cause their microvilli to become motile over the dorsal/apical surface. Their unexpected observations may have implications for epithelial responses in wound healing and disease.
极化上皮细胞在其顶端膜上形成紧密排列的微绒毛阵列，但在伤口愈合过程中上皮细胞极性丧失时，这些微绒毛的命运相对未知。在本期中，克林纳等人（2014年。《细胞生物学杂志》。http://dx.doi.org/10.1083/jcb.201402037）表明，当上皮细胞变得亚汇合时，顶端皮质内局部的肌动球蛋白收缩会导致其微绒毛在背侧/顶端表面上变得可移动。他们意外的观察结果可能对伤口愈合和疾病中的上皮反应有影响。
