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用于微量生物/化学分子微重力传感的先进纳米多孔材料。

Advanced nanoporous materials for micro-gravimetric sensing to trace-level bio/chemical molecules.

作者信息

Xu Pengcheng, Li Xinxin, Yu Haitao, Xu Tiegang

机构信息

State Key Lab of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, 865 Changning Road, Shanghai 200050, China.

出版信息

Sensors (Basel). 2014 Oct 13;14(10):19023-56. doi: 10.3390/s141019023.

DOI:10.3390/s141019023
PMID:25313499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4239959/
Abstract

Functionalized nanoporous materials have been developed recently as bio/chemical sensing materials. Due to the huge specific surface of the nano-materials for molecular adsorption, high hopes have been placed on gravimetric detection with micro/nano resonant cantilevers for ultra-sensitive sensing of low-concentration bio/chemical substances. In order to enhance selectivity of the gravimetric resonant sensors to the target molecules, it is crucial to modify specific groups onto the pore-surface of the nano-materials. By loading the nanoporous sensing material onto the desired region of the mass-type transducers like resonant cantilevers, the micro-gravimetric bio/chemical sensors can be formed. Recently, such micro-gravimetric bio/chemical sensors have been successfully applied for rapid or on-the-spot detection of various bio/chemical molecules at the trace-concentration level. The applicable nanoporous sensing materials include mesoporous silica, zeolite, nanoporous graphene oxide (GO) and so on. This review article focuses on the recent achievements in design, preparation, functionalization and characterization of advanced nanoporous sensing materials for micro-gravimetric bio/chemical sensing.

摘要

功能化纳米多孔材料最近已被开发用作生物/化学传感材料。由于纳米材料具有巨大的比表面积用于分子吸附，人们对利用微/纳米共振悬臂进行重量检测以超灵敏地检测低浓度生物/化学物质寄予厚望。为了提高重量共振传感器对目标分子的选择性，在纳米材料的孔表面修饰特定基团至关重要。通过将纳米多孔传感材料加载到诸如共振悬臂等质量型换能器的所需区域，可以形成微重力生物/化学传感器。最近，这种微重力生物/化学传感器已成功应用于痕量浓度水平下各种生物/化学分子的快速或现场检测。适用的纳米多孔传感材料包括介孔二氧化硅、沸石、纳米多孔氧化石墨烯（GO）等。本文综述聚焦于用于微重力生物/化学传感的先进纳米多孔传感材料在设计、制备、功能化和表征方面的最新进展。

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