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加强常规免疫与全球根除脊髓灰质炎行动之间的伙伴关系,以实现根除目标并确保可持续性。

Strengthening the partnership between routine immunization and the global polio eradication initiative to achieve eradication and assure sustainability.

作者信息

Abdelwahab Jalaa, Dietz Vance, Eggers Rudolf, Maher Christopher, Olaniran Marianne, Sandhu Hardeep, Vandelaer Jos

机构信息

UNICEF, New York City, New York.

Global Immunization Division, CDC, Atlanta, Georgia.

出版信息

J Infect Dis. 2014 Nov 1;210 Suppl 1(Suppl 1):S498-503. doi: 10.1093/infdis/jiu041.

Abstract

Since the launch of the Global Polio Eradication Initiative (GPEI) in 1988, the number of polio endemic countries has declined from 125 to 3 in 2013. Despite this remarkable achievement, ongoing circulation of wild poliovirus in polio-endemic countries and the increase in the number of circulating vaccine-derived poliovirus cases, especially those caused by type 2, is a cause for concern. The Polio Eradication and Endgame Strategic Plan 2013-2018 (PEESP) was developed and includes 4 objectives: detection and interruption of poliovirus transmission, containment and certification, legacy planning, and a renewed emphasis on strengthening routine immunization (RI) programs. This is critical for the phased withdrawal of oral poliovirus vaccine, beginning with the type 2 component, and the introduction of a single dose of inactivated polio vaccine into RI programs. This objective has inspired renewed consideration of how the GPEI and RI programs can mutually benefit one another, how the infrastructure from the GPEI can be used to strengthen RI, and how a strengthened RI can facilitate polio eradication. The PEESP is the first GPEI strategic plan that places strong and clear emphasis on the necessity of improving RI to achieve and sustain global polio eradication.

摘要

自1988年全球根除脊髓灰质炎行动(GPEI)启动以来,脊髓灰质炎流行国家的数量已从125个降至2013年的3个。尽管取得了这一显著成就,但脊髓灰质炎流行国家中野生脊髓灰质炎病毒的持续传播以及疫苗衍生脊髓灰质炎病毒病例数量的增加,尤其是2型病毒引起的病例,令人担忧。《2013 - 2018年脊髓灰质炎根除及终结战略计划》(PEESP)应运而生,该计划包含4个目标:检测并阻断脊髓灰质炎病毒传播、遏制与认证、遗留规划以及重新强调加强常规免疫(RI)计划。这对于分阶段停用口服脊髓灰质炎疫苗(从2型成分开始)以及在常规免疫计划中引入单剂灭活脊髓灰质炎疫苗至关重要。这一目标促使人们重新思考全球根除脊髓灰质炎行动与常规免疫计划如何相互受益、全球根除脊髓灰质炎行动的基础设施如何用于加强常规免疫,以及强化后的常规免疫如何促进脊髓灰质炎根除。《2013 - 2018年脊髓灰质炎根除及终结战略计划》是全球根除脊髓灰质炎行动的首个战略计划,该计划强烈且明确地强调了改善常规免疫对于实现并维持全球脊髓灰质炎根除的必要性。

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