唐氏综合征患者可根据胆碱能功能障碍来鉴别。
People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction.
作者信息
Sacks B, Smith S
机构信息
Department of Psychiatry, Charing Cross and Westminster Medical School, London.
出版信息
J Neurol Neurosurg Psychiatry. 1989 Nov;52(11):1294-5. doi: 10.1136/jnnp.52.11.1294.
Abstract
The mydriatic response to eyedrops of the anticholinergic agent tropicamide at very low concentration (0.01%) has been studied in people with Down's syndrome. By comparison with healthy subjects people with Down's syndrome had responses approximately three times greater, suggesting a peripheral imbalance between cholinergic and adrenergic autonomic influences.
摘要
对唐氏综合征患者使用极低浓度（0.01%）的抗胆碱能药物托吡卡胺滴眼液后的散瞳反应进行了研究。与健康受试者相比，唐氏综合征患者的反应大约大三倍，这表明胆碱能和肾上腺素能自主神经影响之间存在外周失衡。
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