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唐氏综合征患者可根据胆碱能功能障碍来鉴别。

People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction.

作者信息

Sacks B, Smith S

机构信息

Department of Psychiatry, Charing Cross and Westminster Medical School, London.

出版信息

J Neurol Neurosurg Psychiatry. 1989 Nov;52(11):1294-5. doi: 10.1136/jnnp.52.11.1294.

DOI:10.1136/jnnp.52.11.1294
PMID:2531786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1031641/
Abstract

The mydriatic response to eyedrops of the anticholinergic agent tropicamide at very low concentration (0.01%) has been studied in people with Down's syndrome. By comparison with healthy subjects people with Down's syndrome had responses approximately three times greater, suggesting a peripheral imbalance between cholinergic and adrenergic autonomic influences.

摘要

对唐氏综合征患者使用极低浓度（0.01%）的抗胆碱能药物托吡卡胺滴眼液后的散瞳反应进行了研究。与健康受试者相比，唐氏综合征患者的反应大约大三倍，这表明胆碱能和肾上腺素能自主神经影响之间存在外周失衡。

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1
People with Down's syndrome can be distinguished on the basis of cholinergic dysfunction.唐氏综合征患者可根据胆碱能功能障碍来鉴别。
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2
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本文引用的文献

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Atropine in mongolism.阿托品与唐氏综合征
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Atropine response of the eyes in mongolism.蒙古症患者眼睛的阿托品反应。
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Atropine sensitivity and serotonin in mongolism.蒙古症中的阿托品敏感性与血清素
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Am J Ment Defic. 1980 May;84(6):561-7.
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Hyper-reactivity to atropine in Down's syndrome.唐氏综合征患者对阿托品的高反应性。
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8
Anticholinergic sensitivity in patients with dementia of the Alzheimer type and age-matched controls. A dose-response study.阿尔茨海默型痴呆患者及年龄匹配对照组的抗胆碱能敏感性。一项剂量反应研究。
Arch Gen Psychiatry. 1987 May;44(5):418-26. doi: 10.1001/archpsyc.1987.01800170032006.
9
Cholinergic-rich brain transplants reverse alcohol-induced memory deficits.富含胆碱能的脑移植可逆转酒精引起的记忆缺陷。
Nature. 1988 Mar 31;332(6163):448-50. doi: 10.1038/332448a0.
10
Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome.唐氏综合征中神经病理学改变及阿尔茨海默病性痴呆的发生情况。
Ann Neurol. 1985 Mar;17(3):278-82. doi: 10.1002/ana.410170310.